BACE2 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PA1754-Each-of-1 | In Stock | ₹ 50,018.00 |
PA1754 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 50,018.00
GST (18%): ₹ 9,003.24
Total Price: ₹ 59,021.24
Antigen
BACE2
Classification
Polyclonal
Conjugate
Unconjugated
Gene
BACE2
Gene Alias
1110059C24Rik; 56 kDa aspartic-like protease; AEPLC; AI850424; ALP56; ARP1; asp 1; ASP1; ASP21; Aspartic-like protease 56 kDa; Aspartyl protease 1; Bace2; BAE2; be; beta secretase 2; Beta-secretase 2; beta-site amyloid beta A4 precursor protein-cleaving enzyme 2; beta-site amyloid precursor protein cleaving enzyme 2; Beta-site APP cleaving enzyme 2; beta-site APP-cleaving enzyme 2; CDA13; CEAP1; Down region aspartic protease; Down syndrome region aspartic protease; DRAP; memapsin 1; memapsin-1; Membrane-associated aspartic protease 1; theta-secretase; transmembrane aspartic proteinase Asp1; UNQ418/PRO852
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
25825, 56175
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Immunocytochemistry, Western Blot
Concentration
1 mg/mL
Formulation
PBS with 1mg/mL BSA and 0.05% sodium azide
Gene Accession No.
Q9JL18, Q9Y5Z0
Gene Symbols
BACE2
Immunogen
Synthetic Peptide: C P(503) E V V N D E S S L V R H R W K(518)
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human, Mouse
Product Type
Antibody
Isotype
IgG
Related Products
Description
- PA1-754 detects human and mouse beta-secretase 2 (BACE2) from transfected cells
- This product has recently been remanufactured in new rabbits as Cat
- # PA1-1754
- PA1-754 has been successfully used in Western blot and ICC/IF procedures
- By Western blot this antibody detects an ∽58 kDa protein representing BACE2 from SY-SY5Y cells overexpressing the human gene
- The PA1-754 immunogen is amino acid residues 503-518 from human BACE2
- This sequence is completely conserved in mouse
- The PA1-754 immunizing peptide (Cat
- # PEP-167) is available for use in neutralization and control experiments
- BACE2 or Beta Secretase 2 is responsible for the proteolytic processing of the amyloid precursor protein (APP)
- BACE2 cleaves APP between residues 690 and 691
- This cleavage leads to the generation and extracellular release of beta-cleaved soluble APP
- BACE2 is also know to cleave APP between residues 671 and 672
- Accumulation of APP is a signature of Alzheimer disease and frequent complication of adult Down syndrome patients.