PSME1 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PA1960-Each-of-1 | In Stock | ₹ 50,151.50 |
PA1960 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 50,151.50
GST (18%): ₹ 9,027.27
Total Price: ₹ 59,178.77
Antigen
PSME1
Classification
Polyclonal
Conjugate
Unconjugated
Gene
PSME1
Gene Alias
11S regulator complex subunit alpha; 29-kD MCP activator subunit; activator of multicatalytic protease subunit 1; AW413925; epididymis secretory sperm binding protein Li 129m; HEL-S-129m; I79_008549; IFI5111; IGUP I-5111; interferon gamma up-regulated I-5111 protein; interferon-gamma IEF SSP 5111; interferon-gamma-inducible protein 5111; MGC8628; OTTHUMP00000164702; PA28 alpha subunit; PA28a; PA28alpha; protease (prosome, macropain) 28 subunit, alpha; proteasome (prosome, macropain) 28 subunit, alpha; proteasome (prosome, macropain) activator subunit 1; proteasome (prosome, macropain) activator subunit 1 (PA28 alpha); proteasome activator 28 subunit alpha; Proteasome activator complex subunit 1; proteasome activator subunit 1; Psme1; REGalpha; REG-alpha
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
100761736, 19186, 29630, 480256, 5720
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Western Blot
Concentration
1 mg/mL
Formulation
PBS with 1mg/mL BSA and 0.05% sodium azide
Gene Accession No.
P97371, Q06323, Q63797
Gene Symbols
PSME1
Immunogen
Synthetic Peptide: R(5) V Q P E A Q A K V D V F R E D L C(22)
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Canine, Hamster, Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- PA1-960 detects proteasome activator 11S REG alpha subunit from canine, hamster, human, mouse and rat tissues and cells
- PA1-960 has been successfully used in Western blot procedures
- By Western blot, this antibody detects a 28 kDa protein representing 11S REG alpha subunit in rat brain extract
- PA1-960 immunizing peptide corresponds to amino acid residues 5-22 of human proteasome activator 11S REG alpha
- This sequence differs from the mouse and rat 11S REG alpha protein by a single amino acid residue
- PA1-960 immunizing peptide (Cat
- # PEP-097) is available for use in neutralization and control experiments
- Proteolytic degradation is critical to the maintenance of appropriate levels of short-lived and regulatory proteins as important and diverse as those involved in cellular metabolism, heat shock and stress response, antigen presentation, modulation of cell surface receptors and ion channels, cell cycle regulation, transcription, and signalling factors
- The ubiquitin-proteasome pathway deconstructs most proteins in the eukaryotic cell cytosol and nucleus
- Others are degraded via the vacuolar pathway which includes endosomes, lysosomes, and the endoplasmic reticulum
- The 26S proteasome is an ATP-dependent, multisubunit (approximately 31), barrel-shaped molecular machine with an apparent molecular weight of approximately 2.5 MDa
- It consists of a 20S proteolytic core complex which is crowned at one or both ends by 19S regulatory subunit complexes
- The 19S regulatory subunits recognize ubiquitinated proteins and play an essential role in unfolding and translocating targets into the lumen of the 20S subunit
- An enzymatic cascade is responsible for the attachment of multiple ubiquitin molecules to lysine residues of proteins targeted for degradation
- Several genetic diseases are associated with defects in the ubiquitin-proteasome pathway
- Some examples of affected proteins include those linked to cystic fibrosis, Angelman's syndrome, and Liddle syndrome.