PA548231
SIK3 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PA548231-Each-of-1 | In Stock | ₹ 46,502.50 |
PA548231 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
SIK3
Classification
Polyclonal
Conjugate
Unconjugated
Gene
SIK3
Gene Alias
5730525O22Rik; 9030204A07Rik; AI447252; AI846254; AI849445; Kiaa0999; L19; mKIAA0999; QSK; Salt-inducible kinase 3; serine/threonine-protein kinase QSK; Serine/threonine-protein kinase SIK3; SIK family kinase 3; SIK3; SIK-3
Host Species
Rabbit
Purification Method
Antigen affinity chromatography, Protein A
Regulatory Status
RUO
Gene ID (Entrez)
23387
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Flow Cytometry, Western Blot
Concentration
0.5 mg/mL
Formulation
PBS with 0.09% sodium azide
Gene Accession No.
Q9Y2K2
Gene Symbols
SIK3
Immunogen
KLH conjugated synthetic peptide between 1233-1263 amino acids from the C-terminal region of human KIAA0999.
Quantity
400 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- SIK3 (QSK) is a serine/threonine-protein kinase, belongs to QIK subfamily
- The phosphorylation of SIK3 by LKB1 through the 14-3-3 binding enhances its catalytic activity and leads its localization to punctate structures within the cytoplasm
- Overexpression of SIK3 promotes G1/S cell cycle progression with ovarian cancer
- There are two sites (H331L and A1103V) were mutated at significant frequency in breast cancer
- SIK3 is a novel tumor-associated antigen (TAA)
- SIK3 is a positive regulator of mTOR signaling that functions by triggering the degradation of DEPTOR, an mTOR inhibitor
- Involved in the dynamic regulation of mTOR signaling in chondrocyte differentiation during skeletogenesis
- Negatively regulates cAMP signaling pathway possibly by acting on CRTC2/TORC2 and CRTC3/TORC3.