PA548425
Krt222 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PA548425-Each-of-1 | In Stock | ₹ 46,502.50 |
PA548425 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
Krt222
Classification
Polyclonal
Formulation
PBS with 0.09% sodium azide
Gene Accession No.
Q8CCX5, Q8N1A0
Gene Symbols
Krt222
Immunogen
KLH conjugated synthetic peptide between 222-250 amino acids from the C-terminal region of human KRT222P.
Quantity
400 μL
Primary or Secondary
Primary
Target Species
Human, Mouse
Product Type
Antibody
Isotype
IgG
Applications
Western Blot
Conjugate
Unconjugated
Gene
Krt222
Gene Alias
6330509G02Rik; KA21; keratin 222; keratin 222 pseudogene; keratin 222, type II; keratin-222; Keratin-222 pseudogene; keratin-like protein KRT222; Krt222; KRT222P
Host Species
Rabbit
Purification Method
Antigen affinity chromatography, Protein A
Regulatory Status
RUO
Gene ID (Entrez)
125113, 268481
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Related Products
Description
- Predicted to react with bovine based on sequence homology
- KRT222, also known as KRT222P
- KRT222 is a 295 amino acid protein belonging to the intermediate filament family
- The gene encoding KRT222P has been listed as a pseudogene, however it has not been established that the protein is not translated, and is therefore treated as a protein coding gene
- Existing as two alternatively spliced isoforms, the gene encoding KRT222P maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes
- Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1
- Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death
- Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome
- Like p53, BRCA1 is directly involved in DNA repair, though specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes.