CAMSAP3 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PA548993-Each-of-1 | In Stock | ₹ 46,057.50 |
PA548993 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,057.50
GST (18%): ₹ 8,290.35
Total Price: ₹ 54,347.85
Antigen
CAMSAP3
Classification
Polyclonal
Conjugate
Unconjugated
Gene
CAMSAP3
Gene Alias
2310057J16Rik; calmodulin regulated spectrin associated protein family member 3; calmodulin regulated spectrin-associated protein family, member 3; calmodulin-regulated spectrin-associated protein 3; CAMSAP3; KIAA1543; Marshalin; marshalin-La; marshalin-Lb; marshalin-Lc; marshalin-Ld; marshalin-Sa; marshalin-Sb; marshalin-Sc; marshalin-Sd; Nezha; PPP1R80; Protein Nezha; protein phosphatase 1, regulatory subunit 80
Host Species
Rabbit
Purification Method
Antigen affinity chromatography, Protein A
Regulatory Status
RUO
Gene ID (Entrez)
57662, 69697
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Western Blot
Concentration
0.3 mg/mL
Formulation
PBS with 0.09% sodium azide
Gene Accession No.
Q80VC9, Q9P1Y5
Gene Symbols
CAMSAP3
Immunogen
KLH conjugated synthetic peptide between 103-131 amino acids from the N-terminal region of human CAMSAP3.
Quantity
400 μL
Primary or Secondary
Primary
Target Species
Human, Mouse
Product Type
Antibody
Isotype
Ig
Related Products
Description
- Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19041755, PubMed:23169647)
- Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153)
- Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153)
- In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153)
- Required for the biogenesis and the maintenance of zonula adherens by anchoring the minus-end of microtubules to zonula adherens and by recruiting the kinesin KIFC3 to those junctional sites (PubMed:19041755)
- Required for orienting the apical-to-basal polarity of microtubules in epithelial cells: acts by tethering non-centrosomal microtubules to the apical cortex, leading to their longitudinal orientation (PubMed:27802168, PubMed:26715742)
- Plays a key role in early embryos, which lack centrosomes: accumulates at the microtubule bridges that connect pairs of cells and enables the formation of a non-centrosomal microtubule-organizing center that directs intracellular transport in the early embryo
- Couples non-centrosomal microtubules with actin: interaction with MACF1 at the minus ends of non-centrosomal microtubules, tethers the microtubules to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509)
- Plays a key role in the generation of non-centrosomal microtubules by accumulating in the pericentrosomal region and cooperating with KATNA1 to release non-centrosomal microtubules from the centrosome (PubMed:28386021)
- Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:28089391)
- Through interaction with AKAP9, involved in translocation of Golgi vesicles in epithelial cells, where microtubules are mainly non-centrosomal (PubMed:28089391)
- [UniProt]