EAR2 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PA549785-Each-of-1 | In Stock | ₹ 46,502.50 |
PA549785 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
EAR2
Classification
Polyclonal
Conjugate
Unconjugated
Gene
NR2F6
Gene Alias
AV090102; avian erythroblastic leukemia viral (v-erb-a) oncogene homolog-like 2; COUP transcription factor 3; COUPg; COUP-TF3; EAR2; EAR-2; Erba related 2; ERBAL2; ERBA-related gene-2; Nr2f6; Nuclear receptor subfamily 2 group F member 6; nuclear receptor subfamily 2, group F, member 6; nuclear receptor V-erbA-related; orphan nuclear receptor EAR-2; Ovalbumin upstream promoter gamma nuclear receptor; ovalbumin upstream promoter gamma nuclear receptor rCOUPg; v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 2; V-erbA-related protein 2; V-erbA-related protein EAR-2
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
13864, 2063, 245980
Content And Storage
-20°C
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration
1 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.
O09017, P10588, P43136
Gene Symbols
NR2F6
Immunogen
Synthesized peptide derived from N-terminal of human NR2F6.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- The antibody detects endogenous levels of total EAR2 / NR2F6 protein
- Transcription factor predominantly involved in transcriptional repression
- Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors
- Involved in modulation of hormonal responses
- Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene
- Represses the triiodothyronine-dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type-specific manner
- The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6
- Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity
- Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4(+) T cells and may be involved in induction and/or maintenance of peripheral immunological tolerance and autoimmunity
- Involved in development of forebrain circadian clock; is required early in the development of the locus coeruleus (LC).