SIX5 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PA550048-Each-of-1 | In Stock | ₹ 46,502.50 |
PA550048 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
SIX5
Classification
Polyclonal
Conjugate
Unconjugated
Gene
Six5
Gene Alias
BOR2; DM locus-associated homeodomain protein; DM locus-associated homeodomain protein homolog; DMAHP; dystrophia myotonica-associated homeodomain protein; homeobox protein SIX5; MDMAHP; Sine oculis homeobox homolog 5; sine oculis-related homeobox 5; sine oculis-related homeobox 5 homolog; SIX homeobox 5; Six5; TrexBF
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
147912, 20475
Content And Storage
-20°C
Form
Liquid
Applications
Western Blot
Concentration
1 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.
P70178, Q8N196
Gene Symbols
Six5
Immunogen
Synthesized peptide derived from internal of human SIX5.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse
Product Type
Antibody
Isotype
IgG
Related Products
Description
- The antibody detects endogenous levels of total SIX5 protein
- Six5 (homeobox protein SIX5), also known as SIX5, BOR2 or DMAHP (DM locus-associated homeodomain protein), is a transcription factor that is expressed in various structures of the adult eye
- Localized to the cytoplasm in early development and to the nucleus in the later stages of development, Six5 is involved in regulation of organogenesis and in maintenance of retinal formation
- Six5 is able to bind the 5'-TCA[AG][AG]TTNC-3' DNA sequence found in the myogenin and IGFBP5 promoters and, through this binding, can control transcription of the associated mRNA
- Six5 is regulated via association with DACH1 (dachshund homolog 1) and is co-activated by the EYA (eyes absent) proteins
- Defects in the gene encoding Six5 are the cause of branchiooto- renal syndrome type 2 (BOR2), an autosomal disorder characterized by hearing loss, a deep overbite and myopia
- Two isoforms exist due to alternative splicing events.