PA550227
IGSF6 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PA550227-Each-of-1 | In Stock | ₹ 46,502.50 |
PA550227 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
IGSF6
Classification
Polyclonal
Conjugate
Unconjugated
Gene
IGSF6
Gene Alias
DORA; down-regulated by activation (immunoglobulin superfamily); IGSF6; Immunoglobulin superfamily member 6; immunoglobulin superfamily, member 6; Protein DORA
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
10261
Content And Storage
-20°C
Form
Liquid
Applications
Immunohistochemistry (Paraffin)
Concentration
0.4 mg/mL
Formulation
PBS with 40% glycerol and 0.05% sodium azide; pH 7.4
Gene Accession No.
O95976
Gene Symbols
IGSF6
Immunogen
Fusion protein corresponding to a region derived from internal residues of human immunoglobulin superfamily, member 6
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- The antibody detects endogenous levels of total IGSF6 protein
- IGSF6 (DORA), a novel member of the immunoglobulin superfamily (IGSF) from human and rat expressed in dendritic and myeloid cells
- Using a probe from the open reading frame of the rat cDNA, we isolated a cosmid which contains the entire mouse gene
- By comparative analysis and reverse transcriptase polymerase chain reaction, we defined the intron/exon structure and the mRNA of the mouse gene and, with respect to human BAC clones, the human gene
- The genes span 10 kb (mouse) and 12 kb (human), with six exons arranged in a manner similar to other members of the IGSF
- All intron/exon boundaries follow the GT-AG rule
- Expression of the mouse Igsf6 gene is restricted to cells of the immune system, particularly macrophages
- Northern blot revealed a single mRNA of 2.5 kb, in contrast to the human gene which is expressed as two mRNAs of 1 and 2.5 kb
- The human and mouse genes were localized to a locus associated with inflammatory bowel disease
- Analysis of the flanking regions of the Igsf6 gene revealed the presence of an unrelated gene, transcribed from the opposite strand of the DNA and oriented such that the Igsf6 gene is encoded entirely within an intron
- An identical organization is seen in human.