PA550388
CYFIP2 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PA550388-Each-of-1 | In Stock | ₹ 46,502.50 |
PA550388 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
CYFIP2
Classification
Polyclonal
Conjugate
Unconjugated
Gene
CYFIP2
Gene Alias
1500004I01Rik; 6430511D02Rik; AA930218; AU022376; cyfip2; cytoplasmic FMR1 interacting protein 2; cytoplasmic FMR1-interacting protein 2; Kiaa1168; mKIAA1168; p53-inducible protein 121; PIR121
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
26999, 76884
Content And Storage
-20°C
Form
Liquid
Applications
Immunohistochemistry (Paraffin), Western Blot
Concentration
1.2 mg/mL
Formulation
PBS with 40% glycerol and 0.05% sodium azide; pH 7.4
Gene Accession No.
Q5SQX6, Q96F07
Gene Symbols
CYFIP2
Immunogen
Fusion protein corresponding to residues near the C terminal of human cytoplasmic FMR1 interacting protein 2
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse
Product Type
Antibody
Isotype
IgG
Related Products
Description
- The antibody detects endogenous levels of total CYFIP2 / PIR121 protein
- CYFIP2 (Cytoplasmic FMR1-interacting protein 2, p53-inducible protein 121) is a 1,278 amino acid protein encoded by the human gene CYFIP2
- CYFIP2 belongs to the CYFIP family and is involved in T-cell adhesion and p53-dependent induction of apoptosis
- It interacts with FMR1, FXR1 and FXR2 and is a component of the WAVE1 complex composed of Abi-2, CYFIP2, C3orf10/HSPC300, NAP125 and WASF1/WAVE1
- Upon binding to activated Rac 1, CYFIP2 causes the complex to dissociate, releasing activated WASF1
- The CYFIP2 promoter contains a p53-responsive element that confers p53 binding as well as transcriptional activation of a heterologous reporter
- Induced expression of CYFIP2 is sufficient for caspase activation and cellular apoptosis, reminiscent of p53 activation.