TEM5 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PA550672-Each-of-1 | In Stock | ₹ 46,502.50 |
PA550672 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
TEM5
Classification
Polyclonal
Conjugate
Unconjugated
Gene
ADGRA2
Gene Alias
8430414O08Rik; 9530074E10Rik; Adgra2; Adgra3; Adhesion G protein-coupled receptor A2; adhesion G protein-coupled receptor A3; DKFZp434C211; DKFZp434J0911; FLJ14390; G protein-coupled receptor 124; Gpr124; G-protein coupled receptor 124; KIAA1531; LOC100363275; mKIAA1531; Tem5; Tumor endothelial marker 5
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
25960, 78560
Content And Storage
-20°C
Form
Liquid
Applications
Immunohistochemistry (Paraffin), Western Blot
Concentration
1.2 mg/mL
Formulation
PBS with 40% glycerol and 0.05% sodium azide; pH 7.4
Gene Accession No.
Q91ZV8, Q96PE1
Gene Symbols
ADGRA2
Immunogen
Synthetic peptide corresponding to a region derived from internal residues of human G protein-coupled receptor 124
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse
Product Type
Antibody
Isotype
IgG
Related Products
Description
- The antibody detects endogenous levels of total GPR124 / TEM5 protein
- Tumor endothelial markers (TEMs) are significantly up-regulated during angiogenesis and neoangiogensis that are crucial for the growth of solid tumors
- TEMs localized on the cell surface and conserved across species are of particular interest for future development of anti-angiogenic therapies
- These include TEMs such as TEM1, TEM5, TEM7 and TEM8
- TEM5 is a member of the adhesion family of G protein coupled receptors and is localized on the surface of endothelial cells
- TEM5 is a seven-pass transmembrane receptor, unlike TEM1, TEM7 and TEM8 which span the membrane once
- TEM5 is abundantly expressed in tumor vessels, heart, placenta, ovary, small intestine, and colon
- Proteolytically processed soluble TEM5 mediates endothelial cell survival during angiogenesis by linking integrin to glycosaminoglycans.