CTDSP1 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PA550941-Each-of-1 | In Stock | ₹ 46,502.50 |
PA550941 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
CTDSP1
Classification
Polyclonal
Conjugate
Unconjugated
Gene
CTDSP1
Gene Alias
carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1; CTD; CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1; CTD small phosphatase 1; Ctdsp1; GIP; golli-interacting protein; Nif3; Nliif; NLI-IF; NLI-interacting factor 3; Nuclear LIM interactor-interacting factor 3; SCP1; small CTD phosphatase 1; Small C-terminal domain phosphatase 1
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
227292, 363249, 58190
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
ELISA, Immunohistochemistry, Western Blot
Concentration
1 mg/mL
Formulation
PBS with 0.5% BSA, 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.
P58466, Q9GZU7
Gene Symbols
CTDSP1
Immunogen
Synthesized peptide derived from the N-terminal region of human CTDSP1.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- CTDSP1 / NIF3 Polyclonal Antibody detects endogenous levels of CTDSP1 / NIF3 protein
- CTDSP1 is a class 2C phosphatase with activity dependent on the conserved DxD motif
- Expression of CTDSP1 inhibited activated transcription from several promoter-reporter gene constructs, but expression of a mutant lacking phosphatase activity enhanced transcription
- Neuronal gene transcription is repressed in nonneuronal cells by the repressor element-1 (RE1)-silencing transcription factor/neuron-restrictive silencer factor (REST/NRSF; 600571) complex
- REST/NRSF recruits SCPs to neuronal genes that contain RE1 elements, leading to neuronal gene silencing in nonneuronal cells
- Phosphatase-inactive forms of SCP interfere with REST/NRSF function and promote neuronal differentiation of P19 stem cells
- Likewise, small interfering RNA directed to the single Drosophila SCP unmasks neuronal gene expression in S2 cells
- Thus, SCP activity is an evolutionarily conserved transcriptional regulator that acts globally to silence neuronal genes.