THEM5 Polyclonal Antibody, Invitrogen™

Description

• The antibody detects endogenous levels of total THEM5 protein
• THEM5 (thioesterase superfamily member 5) is a 247 amino acid protein that belongs to the thioesterase superfamily
• The gene that encodes THEM5 contains nearly 8,000 bases and maps to human chromosome 1q21.3
• Chromosome 1 is the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome
• There are about 3,000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1
• Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene which encodes lamin A
• When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs
• The mechanism of rapidly enhanced aging is unclear and is a topic of continuing exploration
• The MUTYH gene is located on chromosome 1 and is partially responsible for familial adenomatous polyposis
• Stickler syndrome, Parkinsons, Gaucher disease and Usher syndrome are also associated with chromosome 1
• Has acyl-CoA thioesterase activity towards long-chain (C16 and C18) fatty acyl-CoA substrates, with a preference for linoleyl-CoA and other unsaturated long-chain fatty acid-CoA esters
• Plays an important role in mitochondrial fatty acid metabolism, and in remodeling of the mitochondrial lipid cardiolipin
• Required for normal mitochondrial function.