PC711100UL
MilliporeSigma™ anti-CHIP, Polyclonal
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PC711100UL-Each-of-1 | In Stock | ₹ 49,475.99 |
PC711100UL - Each of 1
In Stock
Quantity
1
Base Price: ₹ 49,475.99
GST (18%): ₹ 8,905.678
Total Price: ₹ 58,381.668
Antigen
CHIP
Classification
Polyclonal
Formulation
Undiluted serum.
Immunogen
a recombinant protein consisting of full-length human CHIP fused to a His·Tag™ sequence
Regulatory Status
RUO
Test Specificity
Recognizes the ∽35kDa CHIP protein. May also detect bands at ∽43, ∽51, and ∽70kDa corresponding to the mono-ubiquitinated, di-ubiquitinated, and dimeric forms of CHIP, respectively.
Content And Storage
−20°C
Isotype
IgG
Applications
Immunofluorescence, Immunoprecipitation
Conjugate
Unconjugated
Host Species
Rabbit
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Drosophila, Hamster, Human, Monkey, Mouse, Rat
Form
Undiluted
Related Products
Description
- Specifically detects CHIP Clone: in Drosophila, Hamster, Human, Monkey, Mouse, Rat samples, and it is validated for Immunofluorescence, Immunoprecipitation CHIP is a U-box dependent E3 ubiquitin ligase and a co-chaperone protein that interacts with Hsc70 and Hsp90 regulating protein triage decisions between folding and degradation
- This occurs through CHIP remodeling the complexes to favor substrate degradation thus providing a molecular link between the chaperone and proteosome machinery
- CHIP has been reported to be involved in the degradation of c-ErbB2/c-Neu, the glucocorticoid receptor, and the cystic fibrosis transmembrane-conductance regulator
- CHIP expression shortens the half-life of both the nascent and mature ErbB2 protein.