TERT Recombinant Rabbit Monoclonal Antibody (19H6L6), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PI702052-Each-of-1 | In Stock | ₹ 49,439.50 |
PI702052 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 49,439.50
GST (18%): ₹ 8,899.11
Total Price: ₹ 58,338.61
Antigen
TERT
Classification
Recombinant Monoclonal
Concentration
0.5 mg/mL
Formulation
PBS with 0.09% sodium azide; pH 7.4
Gene Accession No.
O14746
Gene Symbols
TERT
Immunogen
Protein corresponding to Human TERT (aa 200-400)
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Applications
Immunocytochemistry, Western Blot
Clone
19H6L6
Conjugate
Unconjugated
Gene
TERT
Gene Alias
CMM9; DKCA2; DKCB4; EST2; HEST2; hTERT; hTRT; PFBMFT1; RGD:70494}; TCS1; Telomerase catalytic subunit; telomerase reverse transcriptase; telomerase reverse transcriptase beta; telomerase-associated protein 2; TERT; tert {ECO:0000312; TP2; TR; TRT
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
7015
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
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Description
- This antibody is predicted to react with Monkey, Pig, Dog and Bovine Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
- The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
- Then, individual clones are screened to select the best candidates for production
- The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
- Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG
- The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat
- Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres
- Deregulation of telomerase expression in somatic cells may be involved in oncogenesis
- Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks
- Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase (TERT) have been identified; the full-length sequence of some variants has not been determined
- Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity.