HDAC4 Recombinant Rabbit Monoclonal Antibody (14H4L10), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PI702358-Each-of-1 | In Stock | ₹ 44,544.50 |
PI702358 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 44,544.50
GST (18%): ₹ 8,018.01
Total Price: ₹ 52,562.51
Antigen
HDAC4
Classification
Recombinant Monoclonal
Concentration
0.5 mg/mL
Formulation
PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.
P56524, Q99P99
Gene Symbols
HDAC4
Immunogen
Peptides corresponding to Human HDAC4 (aa 568-585, 147-163)
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human, Rat
Product Type
Antibody
Isotype
IgG
Applications
Western Blot
Clone
14H4L10
Conjugate
Unconjugated
Gene
HDAC4
Gene Alias
4932408F19Rik; AHO3; AI047285; BDMR; DKFZp779K1053; HA6116; HD4; HD7; HD7b; HD9; HDAC; HDAC4; HDAC-4; HDAC7; HDAC7B; HDAC9; HDAC9B; HDAC9FL; HDACA; HDAC-A; HDRP; Histone deacetylase 4; histone deacetylase A; KIAA0288; KIAA0744; MITR
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
363287, 9759
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- This antibody is predicted to react with Monkey, Rat, Pig and Bovine Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
- The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
- Then, individual clones are screened to select the best candidates for production
- The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
- Histone deacetylase 4 (HDAC4) is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3, and H4)
- Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events
- Histone deacetylases act via the formation of large multiprotein complexes
- HDAC4 is also involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D
- It is also involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer
- Mutations to the HDAC4 gene have been found in Brachydactyly-mental retardation syndrome (BDMR).