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PI710306

BDNF Recombinant Polyclonal Antibody (19HCLC), Invitrogen™

Manufacturer: Thermo Scientific

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Pack Size SKU Availability Price
Each of 1 PI710306-Each-of-1 In Stock ₹ 51,798.00

PI710306 - Each of 1

₹ 51,798.00

In Stock

Quantity

1

Base Price: ₹ 51,798.00

GST (18%): ₹ 9,323.64

Total Price: ₹ 61,121.64

Antigen

BDNF

Classification

Recombinant Polyclonal

Concentration

0.5 mg/mL

Formulation

PBS with 0.09% sodium azide

Gene Accession No.

P21237, P23560

Gene Symbols

BDNF

Immunogen

Recombinant protein corresponding to amino acids 129–247 of human BDNF

Quantity

100 μg

Primary or Secondary

Primary

Target Species

Human, Mouse

Product Type

Antibody

Isotype

IgG

Applications

Western Blot

Clone

19HCLC

Conjugate

Unconjugated

Gene

BDNF

Gene Alias

abrineurin; ANON2; anorexia BDNF; Bdnf; BDNF precursor form; bdnf protein; brain derived neurothrophic factor; brain derived neurotrophic factor; brain-derived neurotrophic factor; BULN2; H-BDNF; neurotrophin; ProBDNF

Host Species

Rabbit

Purification Method

Protein A

Regulatory Status

RUO

Gene ID (Entrez)

12064, 627

Content And Storage

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Form

Liquid

Description

  • This antibody is predicted to react with non-human primate, rat and rabbit based on sequence homology
  • Recombinant rabbit polyclonal antibodies are unique offerings from Thermo Fisher Scientific
  • They are comprised of a selection of multiple different recombinant monoclonal antibodies, providing the best of both worlds - the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies - all delivered with the consistency only found in a recombinant antibody
  • While functionally the same as a polyclonal antibody - recognizing multiple epitope sites on the target and producing higher detection sensitivity for low abundance targets - a recombinant rabbit polyclonal antibody has a known mixture of light and heavy chains
  • The exact population can be produced in every lot, circumventing the biological variability typically associated with polyclonal antibody production
  • BDNF (Brain-Derived Neurotrophic Factor) is a member of the neurotrophin family
  • BDNF is synthesized as pre-proBDNF, followed by cleavage to proBDNF
  • Although further processing generates the mature, 14 kDa protein, pro-BDNF is biologically active and is secreted in synaptic vesicles along with the mature form
  • BDNF is widely expressed in the central nervous system and acts in an autocrine and paracrine manner on several classes of neurons
  • Signaling occurs mainly through the tyrosine kinase receptor TrkB, although binding to the lower-affinity receptor, p75-NTR, has also been demonstrated
  • BDNF promotes neuronal survival and differentiation and has been shown to play a critical role in memory formation and synaptic regulation
  • BDNF is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain
  • Expression of BDNF is reduced in both Alzheimer's and Huntington disease patients, and may also play a role in the regulation of stress response and in the biology of mood disorders.