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PI710314

Phospho-Rb (Thr821) Recombinant Polyclonal Antibody (16HCLC), Invitrogen™

Manufacturer: Thermo Scientific

Select a Size

Pack Size SKU Availability Price
Each of 1 PI710314-Each-of-1 In Stock ₹ 49,662.00

PI710314 - Each of 1

₹ 49,662.00

In Stock

Quantity

1

Base Price: ₹ 49,662.00

GST (18%): ₹ 8,939.16

Total Price: ₹ 58,601.16

Antigen

Phospho-Rb (Thr821)

Classification

Recombinant Polyclonal

Concentration

0.5 mg/mL

Formulation

PBS with 0.09% sodium azide

Gene Accession No.

P06400

Gene Symbols

RB1

Immunogen

Phosphopeptide corresponding to amino acids 817–825 of human Retinoblastoma [pT821]

Quantity

100 μg

Primary or Secondary

Primary

Target Species

Human

Product Type

Antibody

Isotype

IgG

Applications

Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot

Clone

16HCLC

Conjugate

Unconjugated

Gene

RB1

Gene Alias

Cleaved Rb; delta RB-p70; DRb-p70; exon 17 tumor GOS561 substitution mutation causes premature stop; GOS563 exon 17 substitution mutation causes premature stop; OSRC; p104; p104 chicken Rb; P105RB; p105-Rb; Phospho-Retinoblastoma; pp105; pp110; PPP1R130; pRb; prepro-retinoblastoma-associated protein; protein phosphatase 1, regulatory subunit 130; rb; RB transcriptional corepressor 1; RB1; Rb-1; Rb-p70; Retin; Retinoblastoma; retinoblastoma 1; retinoblastoma 1 (including osteosarcoma); retinoblastoma 1 protein; retinoblastoma gene; retinoblastoma isoform A; retinoblastoma protein; retinoblastoma suspectibility protein; retinoblastoma tumor suppressor; retinoblastoma-associated protein

Host Species

Rabbit

Purification Method

Protein A

Regulatory Status

RUO

Gene ID (Entrez)

5925

Content And Storage

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Form

Liquid

Description

  • This antibody is predicted to react with mouse, rat, non-human primate and rabbit based on sequence homology
  • Recombinant rabbit polyclonal antibodies are unique offerings from Thermo Fisher Scientific
  • They are comprised of a selection of multiple different recombinant monoclonal antibodies, providing the best of both worlds - the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies - all delivered with the consistency only found in a recombinant antibody
  • While functionally the same as a polyclonal antibody - recognizing multiple epitope sites on the target and producing higher detection sensitivity for low abundance targets - a recombinant rabbit polyclonal antibody has a known mixture of light and heavy chains
  • The exact population can be produced in every lot, circumventing the biological variability typically associated with polyclonal antibody production
  • Rb is a tumor suppressor nuclear phosphoprotein capable of binding to DNA
  • It is phosphorylated on serine and threonine, but not on tyrosine residues
  • It forms a complex with SV40 large T antigen, adenovirus E1A, and human papilloma virus-16 E
  • Rb protein may act by regulating transcription and loss of its function leads to uncontrolled cell growth
  • Aberrations in the RB gene have been implicated in cancers of breast, colon, prostate, kidney, nasopharynx, and leukemia.