Phospho-PKC beta-1 (Thr642) Recombinant Polyclonal Antibody (23HCLC), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PI711723-Each-of-1 | In Stock | ₹ 53,667.00 |
PI711723 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 53,667.00
GST (18%): ₹ 9,660.06
Total Price: ₹ 63,327.06
Antigen
Phospho-PKC beta-1 (Thr642)
Classification
Recombinant Polyclonal
Concentration
0.5 mg/mL
Formulation
PBS with 0.09% sodium azide; pH 7.4
Gene Accession No.
P05771
Gene Symbols
Prkcb
Immunogen
Peptide corresponding to Human PKC-beta (aa Chemically synthesized phosphopeptide derived from a region of human PKCbI that contains threonine 642. The sequence is conserved in rat. (Antigen similar to 44-963G ))
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Applications
Western Blot
Clone
23HCLC
Conjugate
Unconjugated
Gene
Prkcb
Gene Alias
A130082F03Rik; Pkcb; PKC-B; PKC-Beta; Prkcb; Prkcb1; PRKCB2; protein kinase C beta; protein kinase C beta I; protein kinase C beta II; protein kinase C beta type; protein kinase C beta-II; protein kinase C, beta; protein kinase C, beta 1; protein kinase C, beta 1 polypeptide
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
5579
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- This antibody is predicted to react with Monkey, Rat, Bovine and Mouse Recombinant rabbit polyclonal antibodies are unique offerings from Thermo Fisher Scientific
- They are comprised of a selection of multiple different recombinant monoclonal antibodies, providing the best of both worlds - the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies - all delivered with the consistency only found in a recombinant antibody
- While functionally the same as a polyclonal antibody - recognizing multiple epitope sites on the target and producing higher detection sensitivity for low abundance targets - a recombinant rabbit polyclonal antibody has a known mixture of light and heavy chains
- The exact population can be produced in every lot, circumventing the biological variability typically associated with polyclonal antibody production
- The PKC family of serine/threonine kinases, including PRKCB1 (PKC beta I), is activated intracellularly by signal transduction pathways
- In humans, at least 12 different PKC polypeptides have been identified
- These isoforms differ in primary structure, tissue distribution, subcellular localization, mode of action in vitro, response to extracellular signals, and substrate specificity
- PKC alpha, beta I, beta II, and gamma form the conventional family; their activities are Ca2+- and phospholipid-dependent
- Protein kinase C (PKC) can be activated by calcium and second messenger diacylglycerol
- PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways
- PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters
- Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells
- The protein encoded by this gene is one of the PKC family members
- This protein kinase has been reported to be involved in many different cellular functions, such as B cell activation, apoptosis induction, endothelial cell proliferation, and intestinal sugar absorption
- Studies in mice also suggest that this kinase may also regulate neuronal functions and correlate fear-induced conflict behavior after stress
- Alternatively spliced transcript variants encoding distinct isoforms have been reported.