TNF alpha Monoclonal Antibody (E10041), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIM3TNFAI-Each-of-1 | In Stock | ₹ 52,510.00 |
PIM3TNFAI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 52,510.00
GST (18%): ₹ 9,451.80
Total Price: ₹ 61,961.80
Antigen
TNF alpha
Classification
Monoclonal
Concentration
0.5 mg/mL
Formulation
PBS with 10% trehalose and no preservative
Gene Accession No.
P01375, P19101, P23563, P51742
Gene Symbols
Tnf
Immunogen
Recombinant human TNF alpha from Pichia pastoris.
Quantity
500 μg
Primary or Secondary
Primary
Target Species
Canine, Feline, Human, Non-human Primate, Porcine
Product Type
Antibody
Isotype
IgG1
Applications
ELISA, Western Blot
Clone
E10041
Conjugate
Unconjugated
Gene
Tnf
Gene Alias
APC1 protein; Cachectin; C-domain 1; C-domain 2; cTNF; DADB-70P7.1; DIF; ICD1; ICD2; Intracellular domain 1; Intracellular domain 2; N-terminal fragment; NTF; RATTNF; Tnf; TNF alpha; TNF superfamily; TNF a; TNF, macrophage-derived; TNF, monocyte-derived; TNFA; TNF-a; TNFalpha; TNF-alpha; Tnfsf1a; TNFSF2; TNFa; TNLG1F; Tumor necrosis factor; tumor necrosis factor (TNF superfamily, member 2); tumor necrosis factor alpha; tumor necrosis factor alpha (cachetin); tumor necrosis factor alpha precursor; tumor necrosis factor ligand 1F; tumor necrosis factor ligand superfamily member 2; Tumor necrosis factor, membrane form; Tumor necrosis factor, soluble form; tumor necrosis factor-alpha; tumor necrosis factor-alpha precursor; tumor-necrosis factor; tumour necrosis factor
Host Species
Mouse
Purification Method
Protein G
Regulatory Status
RUO
Gene ID (Entrez)
397086, 403922, 493755, 7124
Content And Storage
4° C
Form
Lyophilized
Related Products
Description
- M3TNFAI targets TNF Alpha in ELISA, and WB applications and shows reactivity with Canine, Feline, Human, Non-human primate, and Porcine samples
- The M3TNFAI immunogen is recombinant human TNF alpha from Pichia pastoris
- M3TNFAI detects TNF Alpha which has a predicted molecular weight of approximately 26 kDa
- Endotoxin levels are less than or equal to 10 μg/mL
- TNF alpha is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily
- This cytokine is mainly secreted by macrophage and bind to its receptors, TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR
- TNF alpha is involved in the regulation of immune cells, cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation
- TNF alpha exists as a multimer of two, three, or five noncovalently linked units, but shows a single 17 kDa band following SDS-PAGE under non-reducing conditions
- Knockout studies in mice also suggested the neuroprotective function of TNF alpha, and has been observed to causes tumor necrosis when injected into tumor-bearing mice
- Other functions of TNF-alpha include its role in the immune response to bacterial, viral, parasitic and certain fungal infections, as well as its role in the necrosis of specific tumors
- TNF alpha causes cytolysis or cytostasis of certain transformed cells, being synergistic with interferon-gamma in its cytotoxicity
- This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer.