SHIP1 Monoclonal Antibody (SHIP-01), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA110449-Each-of-1 | In Stock | ₹ 44,544.50 |
PIMA110449 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 44,544.50
GST (18%): ₹ 8,018.01
Total Price: ₹ 52,562.51
Antigen
SHIP1
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
PBS with 15mM sodium azide; pH 7.4
Gene Accession No.
Q92835
Gene Symbols
INPP5D
Immunogen
Peptide coresponding to a sequence within N-terminal domain of Human SHIP-1.
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG2a
Applications
Flow Cytometry, Immunocytochemistry, Western Blot
Clone
SHIP-01
Conjugate
Unconjugated
Gene
INPP5D
Gene Alias
7a33; hp51CN; Inositol polyphosphate-5-phosphatase 145 kDa; inositol polyphosphate-5-phosphatase D; Inositol polyphosphate-5-phosphatase of 145 kDa; inositol polyphosphate-5-phosphatase, 145 kDa; inositol polyphosphate-5-phosphatase, 145kD; inositol polyphosphate-5-phosphatase, 145kDa; Inpp5d; MGC104855; MGC142140; MGC142142; OTTHUMP00000165069; OTTHUMP00000165070; OTTHUMP00000165071; OTTHUMP00000165072; OTTHUMP00000203442; p150Ship; phosphatidylin; Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1; Phosphatidylinositol 4,5-bisphosphate 5-phosphatase; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1; Phosphatidylinositol-4,5-bisphosphate 5-phosphatase; SH2 domain-containing inositol 5'-phosphatase 1; SH2 domain-containing inositol phosphatase 1; SH2 domain-containing inositol-5'-phosphatase 1; SH2-containing inositol phosphatase SHIP; SHIP; SHIP1; SHIP-1; signaling inositol polyphosphate 5 phosphatase SIP-145; signaling inositol polyphosphate phosphatase SHIP II; SIP-145; Src homology 2 domain-containing inositol-5-phosphatase; s-SHIP
Host Species
Mouse
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
3635
Content And Storage
4° C, do not freeze
Form
Liquid
Related Products
Description
- This antibody reacts with SHIP-1, a phosphoinositide phosphatase largely confined to hematopoietic cells
- Multiple forms of SHIP-1 have been reported with molecular weights of 110, 125, 130, 135 and 145 kDa
- Western Blot: Reducing conditions
- This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains
- Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation
- At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways
- Overall, the protein functions as a negative regulator of myeliod cell proliferation and survival
- Alternate transcriptional splice variants, encoding different isoforms, have been characterized.