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PIMA113082

Nesprin 1 Monoclonal Antibody (6A), Invitrogen™

Manufacturer: Thermo Scientific

Select a Size

Pack Size SKU Availability Price
Each of 1 PIMA113082-Each-of-1 In Stock ₹ 40,940.00

PIMA113082 - Each of 1

₹ 40,940.00

In Stock

Quantity

1

Base Price: ₹ 40,940.00

GST (18%): ₹ 7,369.20

Total Price: ₹ 48,309.20

Antigen

Nesprin 1

Classification

Monoclonal

Concentration

1 mg/mL

Formulation

PBS with 1mg/mL BSA and 0.05% sodium azide

Gene Accession No.

Q6ZWR6

Gene Symbols

SYNE1

Immunogen

Recombinant protein containing residues RKLESTLTGLEQSRERQERR

Quantity

100 μg

Primary or Secondary

Primary

Target Species

Mouse, Rat

Product Type

Antibody

Isotype

IgG1

Applications

Western Blot

Clone

6A

Conjugate

Unconjugated

Gene

SYNE1

Gene Alias

8B; A330049M09Rik; ARCA1; BE692247; C130039F11Rik; C6orf98; CPG2; CPG2 full length; dJ45H2.2; DKFZp781J13156; EDMD4; enaptin; enaptin165; FLJ30878; FLJ41140; KASH domain-containing protein 1; KASH1; KIAA0796; KIAA1262; KIAA1756; mKIAA1756; MYNE1; Myne-1; Myocyte nuclear envelope protein 1; Nesp1; nesprin 1; nesprin-1; Nuclear envelope spectrin repeat protein 1; RP1-130E4.2; SCAR8; spectrin repeat containing nuclear envelope protein 1; spectrin repeat containing, nuclear envelope 1; synaptic nuclear envelope 1; synaptic nuclear envelope protein 1; synaptic nuclei expressed gene 1; SYNE 1; SYNE1; Syne-1; syne-1 fragment

Host Species

Mouse

Purification Method

Protein G

Regulatory Status

RUO

Gene ID (Entrez)

499010, 64009

Content And Storage

-20°C

Form

Liquid

Description

  • There are two genes encoding members of a new family of type II integral membrane proteins
  • Both are ubiquitously expressed, and tissue-specific alternative mRNA initiation and splicing generate at least two major isoforms of each protein, with the smaller isoforms being truncated at the N-terminus
  • These proteins are called nesprin-l and -2 for nuclear _envelope _spectrin repeat, as they are characterized by the presence of multiple, clustered spectrin repeats, bipartite nuclear localization sequences and a conserved C-terminal, single transmembrane domain
  • Transient transfection of EGFP-fusion expression constructs demonstrated their localization to the nuclear membrane with a novel C-terminal, TM-domain-containing sequence essential for perinuclear localization
  • Nesprin-l is developmentally regulated in both smooth and skeletal muscle and is relocalized from the nuclear envelope to the nucleus and cytoplasm during C2Cl2 myoblast differentiation
  • Nesprins may function as 'dystrophins of the nucleus' to maintain nuclear organization and structura integrity.