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PIMA1134

RhoA Monoclonal Antibody (1B8-1C7), Invitrogen™

Manufacturer: Thermo Scientific

Select a Size

Pack Size SKU Availability Price
Each of 1 PIMA1134-Each-of-1 In Stock ₹ 51,264.00

PIMA1134 - Each of 1

₹ 51,264.00

In Stock

Quantity

1

Base Price: ₹ 51,264.00

GST (18%): ₹ 9,227.52

Total Price: ₹ 60,491.52

Antigen

RhoA

Classification

Monoclonal

Concentration

1 mg/mL

Formulation

PBS with 1mg/mL BSA and 0.05% sodium azide

Gene Accession No.

P61586, P61589, Q9QUI0

Gene Symbols

RHOA

Immunogen

Full-length recombinant His-tagged human RhoA

Quantity

100 μg

Primary or Secondary

Primary

Target Species

Human, Mouse, Rat

Product Type

Antibody

Isotype

IgG1

Applications

Western Blot

Clone

1B8-1C7

Conjugate

Unconjugated

Gene

RHOA

Gene Alias

Aplysia ras-related homolog 12; Aplysia RAS-related homolog 6; aplysia ras-related homolog A; aplysia ras-related homolog A1; aplysia ras-related homolog A2; ARH12; ARH6; ARH9; ARHA; Arha1; Arha2; ARHB; ARHC; h12; h6; H9; MGC72339; MST081; MSTP081; oncogene RHO H12; oncogene RHO H6; oncogene RHO H9; plysia ras-related homolog A2; Ras family member A; ras homolog A1; ras homolog A2; ras homolog family member A; ras homolog family member B; ras homolog family member C; ras homolog gene family, member A; ras homolog gene family, member A1; ras homolog gene family, member A2; ras homolog gene family, member B; ras homolog gene family, member C; RAS-related homolog 9; Rho; Rho cDNA clone 12; Rho cDNA clone 6; rho cDNA clone 9; Rho family GTPase; RHO12; Rhoa; RHOB; RHOC; rhoC GTPase; RHOH12; RHOH6; RHOH9; rho-related GTP-binding protein RhoB; Rho-related GTP-binding protein RhoC; small GTP binding protein RhoA; small GTP binding protein RhoC; transforming protein RhoA

Host Species

Mouse

Purification Method

Protein A

Regulatory Status

RUO

Gene ID (Entrez)

117273, 11848, 387

Content And Storage

-20°C

Form

Liquid

Description

  • By Western blot, MA1-134 detects recombinant RhoA, but not recombinant RhoB or recombinant RhoC
  • By Western blot on mouse and rat kidney whole tissue lysates, MA1-134 detects a band of ∽22kD corresponding to the expected molecular weight of RhoA
  • A nonspecific band at ∽55kD was also detected in both kidney lysates
  • RhoA regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers
  • It is involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis, and plays an essential role in cleavage furrow formation
  • RhoA is required for the apical junction formation of keratinocyte cell-cell adhesion, and serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders
  • RhoA stimulates PKN2 kinase activity and may be an activator of PLCE1
  • It is activated by ARHGEF2, which promotes the exchange of GDP for GTP
  • It is essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly
  • The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex
  • It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity
  • In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization.