PKA alpha Monoclonal Antibody (6D2.1), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA119732-Each-of-1 | In Stock | ₹ 46,947.50 |
PIMA119732 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,947.50
GST (18%): ₹ 8,450.55
Total Price: ₹ 55,398.05
Antigen
PKA alpha
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
PBS with 15mM sodium azide; pH 7.4
Gene Accession No.
P17612
Gene Symbols
PRKACA
Immunogen
Synthetic peptide corresponding to residues ESPAQNTAHLDQFERIK of human proteinkinase Ac alpha (PKAc alpha).
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG1
Applications
Dot Blot, Western Blot
Clone
6D2.1
Conjugate
Unconjugated
Gene
PRKACA
Gene Alias
alternatively spliced; C(s); Calpha; C-alpha-2; C-alpha-S; cAMP-dependent protein kinase catalytic subunit alpha; cAMP-dependent protein kinase catalytic subunit alpha, isoform 1; cAMP-dependent protein kinase catalytic subunit C alpha; cAMP-dependent protein kinase catalytic subunit Calpha1; Cs-PKA; MGC102831; MGC48865; PKA; PKA C-alpha; PKA catalytic subunit alpha; pkac; Pkaca; PKCA1; PKCD; PPNAD4; PRKACA; protein kinase; protein kinase A; protein kinase A alpha; protein kinase A catalytic subunit; protein kinase cAMP-activated catalytic subunit alpha; protein kinase, cAMP dependent, catalytic, alpha; protein kinase, cAMP-dependent, alpha catalytic subunit; protein kinase, cAMP-dependent, catalytic, alpha; sperm cAMP-dependent protein kinase catalytic subunit; sperm cAMP-dependent protein kinase catalytic subunit Cs
Host Species
Mouse
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
5566
Content And Storage
4° C, do not freeze
Form
Liquid
Related Products
Description
- This antibody reacts with human protein kinase A catalytic (PKAc) alpha subunit, and weakly with PKAc gamma subunit (both around 40 kDa)
- The recognized epitope of PKAc alpha is identical between man, sheep, pig, ox and dog
- MA1-19732 detects PKAc alpha in WB application with human samples
- Western Blot: To detect PKAc gamma, use a more concentrated lysate from a tissue expressing this subunit (testis)
- Protein kinase A (PKA, cAMP-dependent protein kinase) is a key element of a ubiquitous signaling pathway important in the cell cycle, cellular communication, memory formation and behavior
- PKA is composed of two catalytic (PKAc; Protein Kinase A catalytic subunit) and two regulatory subunits (PKAr)
- Upon binding cAMP, the complex dissociates to PKAr dimer and two activated PKAc ser/thr protein kinase catalytic monomers
- The released PKAc can translocate into the nucleus and exert a regulatory role in the activation of multiple nuclear hormone receptors
- However, PKAc-mediated activation of tonicity-dependent gene expression is cAMP independent
- Humans express three types of PKAc subunit - PKAc alpha is present in most human tissues, PKAc beta and gamma are tissue-specific, the later is found in testes.