CD146 Monoclonal Antibody (P1H12), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA125100-Each-of-1 | In Stock | ₹ 47,036.50 |
PIMA125100 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 47,036.50
GST (18%): ₹ 8,466.57
Total Price: ₹ 55,503.07
Antigen
CD146
Classification
Monoclonal
Concentration
1.9 mg/mL
Formulation
0.01M PBS with 15mM sodium azide; pH 7.4
Gene Accession No.
P43121
Gene Symbols
MCAM
Immunogen
Human umbilical cord cells.
Quantity
50 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG1
Applications
ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Frozen), Immunoprecipitation, Western Blot
Clone
P1H12
Conjugate
Unconjugated
Gene
MCAM
Gene Alias
1-gicerin; AV025631; CD146; CD149; Cell surface glycoprotein MUC18; cell surface glycoprotein P1H12; Gicerin; HEMCAM; l-gicerin; l-gicerin precursor; l-gicerin protein; LOW QUALITY PROTEIN: cell surface glycoprotein MUC18; MCAM; melanoma adhesion molecule; melanoma cell adhesion molecule; Melanoma-associated antigen A32; melanoma-associated antigen MUC18; Muc18; mucin-18; s-endo; S-endo 1 endothelial-associated antigen; s-gicerin; s-gicerin precursor
Host Species
Mouse
Purification Method
purified
Regulatory Status
RUO
Gene ID (Entrez)
4162
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- Recommended positive controls: human tongue
- Store product as a concentrated solution
- Centrifuge briefly prior to opening the vial
- CD146 (MCAM) is an integral membrane glycoprotein belonging to the immunoglobulin superfamily
- CD146 is expressed at cell-cell junctions in all endothelial cells, and has also been observed in other normal and malignant cell types
- In addition to its recognized role as a calcium-independent cell adhesion molecule, CD146 may also act as a signal transduction molecule in the recruitment of Fyn kinase, and in the subsequent tyrosine-phosphorylation of intracellular proteins involved in actin cytoskeleton assembly
- CD146 plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue
- CD146 expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread
- Further, CD146 could be an adhesion molecule active in neural crest cells during embryonic development
- CD146 acts also as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2, and a transient increase in the intracellular calcium concentration.