CD11b/c Monoclonal Antibody (OX-42), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA180774-Each-of-1 | In Stock | ₹ 98,434.00 |
PIMA180774 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 98,434.00
GST (18%): ₹ 17,718.12
Total Price: ₹ 1,16,152.12
Antigen
CD11b/c
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.
0
Gene Symbols
Itgam, Itgax
Immunogen
Rat peritoneal macrophages.
Quantity
1 mg
Primary or Secondary
Primary
Target Species
Rat
Product Type
Antibody
Isotype
IgG2a
Applications
Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Frozen), Immunoprecipitation
Clone
OX-42
Conjugate
Unconjugated
Gene
Itgam
Gene Alias
AI449405; antigen CD11b (p170); CD11 antigen-like family member B; CD11 antigen-like family member C; CD11b; CD11B (p170); CD11b/CD18; CD11bc; CD11C; CD11C (p150) alpha polypeptide; cell surface glycoprotein MAC-1 alpha subunit; cell surface glycoprotein MAC-1 subunit alpha; complement component 3 receptor 3 subunit; complement component 3 receptor 4 subunit; complement component receptor 3 alpha-a; complement receptor 4; complement receptor type 3; CR3; CR-3 alpha chain; CR3A; Cr4; F730045J24Rik; integrin alpha M; integrin alpha X; integrin alpha-M; Integrin alpha-X; integrin aX; integrin subunit alpha M; integrin subunit alpha X; integrin, alpha M; integrin, alpha M (complement component 3 receptor 3 subunit); integrin, alpha X; integrin, alpha X (antigen CD11C (p150), alpha polypeptide); integrin, alpha X (complement component 3 receptor 4 subunit); ITGAM; ITGAX; Leu M5; leu M5, alpha subunit; leukocyte adhesion glycoprotein p150,95 alpha chain; Leukocyte adhesion receptor MO1; leukocyte adhesion receptor p150,95; leukocyte surface antigen p150,95, alpha subunit; Ly-40; MAC1; MAC-1; Mac-1 alpha; MAC1A; Mac-1a; macrophage antigen alpha; macrophage antigen alpha polypeptide; MGC117044; MO1A; myeloid membrane antigen, alpha subunit; N418; Neutrophil adherence receptor; neutrophil adherence receptor alpha-M subunit; OX42; OX-42; p150 95 integrin alpha chain; RGD1561123; SLEB6
Host Species
Mouse
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
25021, 499271
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- For FACS analysis, use 10 μL of the suggested working dilution to label 1x10^6 cells in 100 μL
- Mouse anti Rat CD11b, clone OX-42, recognizes rat CD11b, also known as integrin alpha-M, the receptor for the iC3b component of complement
- CD11b is a 1151 amino acid single pass type 1 transmembrane glycoprotein posessing a single vWFA domain and multiple FG-GAP repeats
- Mouse anti Rat CD11b, clone OX-42, recognizes rat CD11b, also known as integrin alpha-M, the receptor for the iC3b component of complement
- CD11b is a 1151 amino acid single pass type 1 transmembrane glycoprotein posessing a single vWFA domain and multiple FG-GAP repeats
- Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain
- CD11b is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement coated particles
- It is identical to CR3, the receptor for the iC3b fragment of the third complement component
- CD11b is also a receptor for fibrogen, factor X and ICAM1
- It recognizes P1 and P2 peptides of fibrogen gamma chain
- The Mac1 CD11b antigen is present on macrophages, granulocytes, natural killer cells, blood monocytes
- CD11b is expressed on 8% spleen cells, 44% bone marrow cells and less than 1% thymocytes and is commonly used as a microgial marker in nervous tissue
- CD11c encodes the integrin alpha X chain protein
- This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4)
- The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles
- Mutations affecting the CD11b/c gene lead to systemic lupus erythematosus 6.