Complement C3b Monoclonal Antibody (H11), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA182934-Each-of-1 | In Stock | ₹ 98,968.00 |
PIMA182934 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 98,968.00
GST (18%): ₹ 17,814.24
Total Price: ₹ 1,16,782.24
Antigen
Complement C3b
Classification
Monoclonal
Concentration
50 μg/mL
Formulation
PBS with 0.5% BSA and 0.09% sodium azide; pH 7.4
Gene Accession No.
P01024
Gene Symbols
C3
Immunogen
Human C3b
Quantity
50 μg
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG1
Applications
Immunohistochemistry (Frozen), Western Blot
Clone
H11
Conjugate
Unconjugated
Gene
C3
Gene Alias
Acylation stimulating protein; acylation-stimulating protein cleavage product; AHUS5; AI255234; ARMD9; ASP; C3; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1; C3a; C3a anaphylatoxin; C3adesArg; C3b; C3bc; C3-beta-c; Complement C3; Complement C3 alpha chain; Complement C3 beta chain; Complement C3b alpha' chain; Complement C3c alpha' chain fragment 1; Complement C3c alpha' chain fragment 2; Complement C3d fragment; Complement C3dg fragment; Complement C3f fragment; Complement C3g fragment; complement component 3; complement component C3a; complement component C3b; CPAMD1; ENCF-1; ENCF-2; epididymis secretory sperm binding protein Li 62p; HEL-S-62p; HSE-MSF; iC3b; Neutrophil chemotactic factor-1; Neutrophil chemotactic factor-2; Plp; prepro-C3
Host Species
Mouse
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
718
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Lyophilized
Related Products
Description
- Reconstitute with 1 mL of distilled water
- After reconstitution, store product undiluted at 4oC or -20oC if preferred
- Mouse anti Human C3b antibody, clone H11 recognizes human C3b, part of the complement system
- Inactive complement component 3b (iC3b) is a 42kDa neoantigen present in blood serum
- Cleavage of C3b into iC3b by the protease factor I, in the presence of cofactors, changes the structure and resulting binding properties, preventing binding by complement factor B and properdin
- This prevents further progression of the complement pathway, providing another mechanism by which the complement pathway may be regulated
- iC3b is thought to play a role in inducing tolerance, binding complement receptor type 3 on antigen presenting cells and stimulating them to produce transforming growth factor beta2 and interleukin-10
- It is thought to stimulate B-cells via the CD21 receptor providing a link between the innate and adaptive immune responses
- Additionally iC3b acts as an opsonin which is recognised by complement receptor 3 expressed on leukocytes or complement receptor of the immunoglobulin superfamily (CRIg) on Kupffer cells, stimulating phagocytosis of the tagged cells
- iC3b levels are often elevated in diseases such as Systemic Lupus Erythematosis and Rheumatoid arthritis.