ErbB3 Monoclonal Antibody (2C3), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA513053-Each-of-1 | In Stock | ₹ 52,465.50 |
PIMA513053 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 52,465.50
GST (18%): ₹ 9,443.79
Total Price: ₹ 61,909.29
Antigen
ErbB3
Classification
Monoclonal
Concentration
0.2 mg/mL
Formulation
PBS with 0.2% BSA and 0.09% sodium azide; pH 7.4
Gene Accession No.
P21860, Q61526, Q62799
Gene Symbols
ERBB3
Immunogen
Recombinant rat c-erbB-3/HER-3 oncoprotein
Quantity
500 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG1
Applications
Immunoprecipitation, Western Blot
Clone
2C3
Conjugate
Unconjugated
Gene
ERBB3
Gene Alias
avian erythroblastosis oncogene B 3; avian erythroblastosis oncogene B 3 receptor; C76256; c-erbB3; c-erbB-3; C-errB-3; erb-b2 receptor tyrosine kinase 3; ERBB3; Erbb-3; Erbb3r; erbB3-S; glial growth factor receptor; HER3; human epidermal growth factor receptor 3; LCCS2; MDA BF 1; MDA-BF-1; MGC88033; nuc-ErbB3; p180 ErbB3; p180-ErbB3; p45 sErbB3; p45-sErbB3; p85 sErbB3; p85-sErbB3; proto-oncogene-like protein c-ErbB-3; receptor tyrosine kinase; receptor tyrosine-protein kinase erbB-3; receptor tyrosine-protein kinase erbB-3; LOW QUALITY PROTEIN: receptor tyrosine-protein kinase erbB-3; tyrosine kinase-type cell surface receptor HER3; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3; v-erb-b2 erythroblastic leukemia viral oncogene homolog 3; v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
Host Species
Mouse
Purification Method
Protein G
Regulatory Status
RUO
Gene ID (Entrez)
13867, 2065, 29496
Content And Storage
4° C
Form
Liquid
Related Products
Description
- MA5-13053 targets HER-3 in IP and WB applications and shows reactivity with Human, mouse, and Rat samples
- The MA5-13053 immunogen is recombinant rat c-erbB-3/HER-3 oncoprotein
- ErbB3 (c-erbB-3/HER-3) is a member of the type I family of growth factor receptors and binds to ligands in the heregulin family
- ErbB3 is over-expressed in a variety of tumors in the prostate, bladder, breast, stomach, pancreas, and colon
- Heregulin and EGF stimulate tyrosine phosphorylation of c-erbB-3 to different extents
- The ErbB3 gene is located on the long arm of human chromosome 12 (12q13) and is transcribed into a 6
- 2kb mRNA which is translated into a 160/180 kDa glycoprotein
- The ErbB3 gene encodes a transmembrane receptor tyrosine kinase due to alternative splicing and forms heterodimers with other EGF receptor family members that have kinase activity
- Heterodimerization leads to the activation of pathways that lead to cell proliferation or differentiation
- Alternate transcriptional splice variants encoding different isoforms of ErbB3 have been characterized
- One ErbB3 isoform lacks the intermembrane region, is secreted outside the cell, and acts to modulate the activity of the membrane-bound form
- Additional splice variants have also been reported, but they have not been thoroughly characterized.