PIMA514947
Phospho-IRF3 (Ser396) Monoclonal Antibody (E.875.8), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA514947-Each-of-1 | In Stock | ₹ 47,125.50 |
PIMA514947 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 47,125.50
GST (18%): ₹ 8,482.59
Total Price: ₹ 55,608.09
Antigen
Phospho-IRF3 (Ser396)
Classification
Monoclonal
Concentration
46 μg/mL
Formulation
0.01M HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and <0.02% sodium azide; pH 7.5
Gene Accession No.
P70671, Q14653
Gene Symbols
IRF3
Immunogen
Synthetic phosphopeptide corresponding to residues surrounding pSer396 of human IRF-3
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse
Product Type
Antibody
Isotype
IgG
Applications
Western Blot
Clone
E.875.8
Conjugate
Unconjugated
Gene
IRF3
Gene Alias
C920001K05Rik; IIAE7; Interferon regulatory factor 3; IRF3; IRF-3; IRF3 (phospho S386); IRF3 (pS386); IRF3 (pSer386); IRF3 phospho; IRF3 phospho S386; IRF3 phospho Ser386; phospho IRF3
Host Species
Rabbit
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
3661, 54131
Content And Storage
-20°C
Form
Liquid
Related Products
Description
- It is not recommended to aliquot this antibody
- IFR3 (interferon regulatory factor 3) is a key transcriptional regulator of type I interferon (IFN)-dependent immune responses
- It plays a critical role in the innate immune response against DNA and RNA viruses
- IFR3 regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters
- It acts as a more potent activator of the IFN-beta gene than the IFN-alpha gene and plays a critical role in both the early and late phases of the IFNA/B gene induction
- IFR3 is found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA, or toll-like receptor signaling
- It is phosphorylated by IKBKE and TBK1 kinases
- This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes
- Mutations in the gene can result in encephalopathy, acute, infection-induced, herpes-specific 7.