HP1 alpha Monoclonal Antibody (F.747.6), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA514989-Each-of-1 | In Stock | ₹ 42,453.00 |
PIMA514989 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 42,453.00
GST (18%): ₹ 7,641.54
Total Price: ₹ 50,094.54
Antigen
HP1 alpha
Classification
Monoclonal
Conjugate
Unconjugated
Gene
Cbx5
Gene Alias
2610029O15Rik; antigen p25; C75991; Cbx5; Cbx5 antibody; chromobox 5; chromobox homolog 5; chromobox homolog 5 (HP1 alpha homolog, Drosophila); chromobox protein homolog 5; chromobox-like protein 5; epididymis luminal protein 25; HEL25; heterochromatin protein 1 alpha; heterochromatin protein 1 homolog alpha; heterochromatin protein 1-alpha; HGNC:1555; HP1; HP1 alpha; HP-1 alpha antibody; HP1 alpha homolog; Hp1a; Hp1alpha; HP1-ALPHA; HP1Hs alpha; HP1Hs-alpha; mHP1(alpha)
Host Species
Rabbit
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
12419, 23468, 300266
Content And Storage
-20°C
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Clone
F.747.6
Formulation
0.01M HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and <0.02% sodium azide; pH 7.5
Gene Accession No.
P45973, Q61686
Gene Symbols
Cbx5
Immunogen
Synthetic peptide corresponding to the carboxy terminus of human HP1 a
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Non-human Primate, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- It is not recommended to aliquot this antibody
- This antibody is not cross-reactive with HP1 -gamma proteins
- Heterochromatin protein-1 (HP1) is a methyl-lysine binding protein localized at heterochromatin sites, where it mediates gene silencing
- It has been shown that mammalian methyltransferases that selectively methylate histone H3 on lysine-9 generate a binding site for HP1 proteins, a family of heterochromatic adaptor molecules implicated in both gene silencing and supranucleosomal chromatin structure
- High-affinity in vitro recognition of a methylated histone H3 peptide by HP1 requires a functional chromodomain
- Thus, the HP1 chromodomain is a specific interaction motif for the methyl epitope on lysine-9 of histone H3
- In vivo, heterochromatin association of HP1 proteins is lost in Suv39h double-null primary mouse fibroblasts but is restored after reintroduction of a catalytically active SUV39H1 HMTase.