LSD1 Monoclonal Antibody (E.289.8), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA515026-Each-of-1 | In Stock | ₹ 41,385.00 |
PIMA515026 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 41,385.00
GST (18%): ₹ 7,449.30
Total Price: ₹ 48,834.30
Antigen
LSD1
Classification
Monoclonal
Conjugate
Unconjugated
Gene
KDM1A
Gene Alias
1810043O07Rik; AA408884; amine oxidase (flavin containing) domain 2; AOF2; BHC110; BRAF35-HDAC complex protein BHC110; CPRF; D4Ertd478e; FAD-binding protein BRAF35-HDAC complex, 110 kDa subunit; flavin-containing amine oxidase domain-containing protein 2; KDM1; KDM1A; KIAA0601; Lsd1; lysine (K)-specific demethylase 1; lysine (K)-specific demethylase 1A; lysine demethylase 1A; lysine-specific demethylase 1; lysine-specific histone demethylase 1; lysine-specific histone demethylase 1A; mKIAA0601; neuroprotective protein 3; RGD1562975; RP1-184J9.1; wu:fb82e06; wu:fc51a02; wu:fj36a05; wu:fj66b06
Host Species
Mouse
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
23028, 500569, 99982
Content And Storage
-20°C
Form
Liquid
Applications
Western Blot
Clone
E.289.8
Formulation
0.01M HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and <0.02% sodium azide; pH 7.5
Gene Accession No.
O60341, Q6ZQ88
Gene Symbols
KDM1A
Immunogen
Recombinant human LSD1 protein
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Non-human Primate, Rat
Product Type
Antibody
Isotype
IgG1
Related Products
Description
- It is not recommended to aliquot this antibody
- LSD1 is a histone demethylase that specifically demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor
- LSD1 contains a SWIRM domain, a FAD-binding motif, and an amine oxidase domain
- This protein is a component of several histone deacetylase complexes, though it silences genes by functioning as a histone demethylase
- It acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed
- LSD1 demethylates both mono- and tri-methylted 'Lys-4' of histone H3
- This protein may play a role in the repression of neuronal genes
- Alone, it is unable to demethylate H3 'Lys-4' on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity
- It may also demethylate 'Lys-9' of histone H3, a specific tag for epigenetic transcriptional repression, thereby leading to derepression of androgen receptor target genes
- Mutations affecting this gene can result in cleft palate, psychomotor retardation, and distintive facial features.