PIMA515136
LIMK2 Monoclonal Antibody (T.756.1), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA515136-Each-of-1 | In Stock | ₹ 47,481.50 |
PIMA515136 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 47,481.50
GST (18%): ₹ 8,546.67
Total Price: ₹ 56,028.17
Antigen
LIMK2
Classification
Monoclonal
Conjugate
Unconjugated
Gene
LIMK2
Gene Alias
EC 2.7.11.1; kinase LIMK2; LIM domain kinase 2; LIM kinase 2; LIM motif-containing protein kinase 2; LIMK; LIMK 2; LIMK1; LIMK-1; Limk2; LIMK-2; Limk2b; LINhp-2; Link2; OTTHUMP00000199483
Host Species
Rabbit
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
3985
Content And Storage
-20°C
Form
Liquid
Applications
Western Blot
Clone
T.756.1
Formulation
0.01M HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and <0.02% sodium azide; pH 7.5
Gene Accession No.
P53671
Gene Symbols
LIMK2
Immunogen
Synthetic peptide corresponding to carboxy-terminal residues of human LIMK2
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Non-human Primate
Product Type
Antibody
Isotype
IgG
Related Products
Description
- It is not recommended to aliquot this antibody
- This antibody is not cross-reactive with LIMK1
- LIMK2 is a serine/threonine kinase involved in regulation of actin cytoskeletal changes via phosphorylation of cofilin
- LIMK2 has also been implicated in brain development
- Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions
- LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain
- The protein encoded by LIMK2 is phosphorylated and activated by ROCK, a downstream effector of Rho, and the encoded protein, in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity
- It is thought that this pathway contributes to Rho-induced reorganization of the actin cytoskeleton
- At least three transcript variants encoding different isoforms have been found for LIMK2.