Bcl-xL Monoclonal Antibody (C.85.1), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA515142-Each-of-1 | In Stock | ₹ 53,311.00 |
PIMA515142 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 53,311.00
GST (18%): ₹ 9,595.98
Total Price: ₹ 62,906.98
Antigen
Bcl-xL
Classification
Monoclonal
Concentration
144 μg/mL
Formulation
0.01M HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and <0.02% sodium azide; pH 7.5
Gene Accession No.
P53563, Q07817, Q64373
Gene Symbols
BCL2L1
Immunogen
Synthetic peptide corresponding to residues surrounding Asp61 of human Bcl-xL
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Non-human Primate, Rat
Product Type
Antibody
Isotype
IgG
Applications
Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Clone
C.85.1
Conjugate
Unconjugated
Gene
BCL2L1
Gene Alias
anti-apoptosis regulatory protein; apoptosis regulator Bcl-X; B cell lymphoma 2 like; B cell lymphoma like X; B-cell leukemia/lymphoma x; Bcl(X)L; BCL2 like 1; Bcl2l; BCL2L1; bcl2-L-1; BCL2-like 1; Bcl-2-like protein 1; BCLX; bcl-x; BCLXL; Bcl-XL; BCL-XL/S; BCLXS; bcl-xS; Blc2l; DKFZp781P2092; EGK_02534; OTTHUMP00000030550; OTTHUMP00000030552; OTTHUMP00000030555; OTTHUMP00000030556; OTTHUMP00000030557; PPP1R52; protein phosphatase 1, regulatory subunit 52; RP5-857M17.3
Host Species
Rabbit
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
12048, 24888, 598
Content And Storage
-20°C
Form
Liquid
Related Products
Description
- It is not recommended to aliquot this antibody
- This antibody is not cross-reactive with other Bcl-2 family members
- BCL-XL is a part of the BCL-2 protein family
- BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities
- BCL-XL is located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening
- VDAC regulates mitochondrial membrane potential and controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis
- Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported
- The longer isoform acts as an apoptotic inhibitor and the shorter form acts as an apoptotic activator.