XBP1 Monoclonal Antibody (1C4), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA515626-Each-of-1 | In Stock | ₹ 50,062.50 |
PIMA515626 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 50,062.50
GST (18%): ₹ 9,011.25
Total Price: ₹ 59,073.75
Antigen
XBP1
Classification
Monoclonal
Concentration
Conc. Not Determined
Formulation
ascites with 0.03% sodium azide
Gene Accession No.
P17861
Gene Symbols
Xbp1
Immunogen
Purified recombinant fragment of human XBP1 expressed in E. Coli.
Regulatory Status
RUO
Gene ID (Entrez)
7494
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
ELISA, Western Blot
Clone
1C4
Conjugate
Unconjugated
Gene
Xbp1
Gene Alias
D11Ertd39e; Hepatocarcinogenesis-related transcription factor; HTF; OTTHUMP00000028682; Tax-responsive element-binding protein 5; tax-responsive element-binding protein 5 homolog; TREB5; TREB-5; X-box binding protein 1; X-box-binding protein 1; X-box-binding protein 1, cytoplasmic form; X-box-binding protein 1, luminal form; XBP1; XBP-1; XBP2
Host Species
Mouse
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG1
Related Products
Description
- MA5-15626 targets XBP1 in indirect ELISA, WB applications and shows reactivity with Human samples
- The MA5-15626 immunogen is purified recombinant fragment of human XBP1 expressed in E
- Coli
- MA5-15626 detects XBP1 which has a predicted molecular weight of approximately 28kDa
- XBP1 encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box
- This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter
- It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator
- It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1)
- The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor
- The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress
- A pseudogene of XBP1 has been identified and localized to chromosome 5.