PIMA515632
JAK2 Monoclonal Antibody (1C1), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA515632-Each-of-1 | In Stock | ₹ 52,732.50 |
PIMA515632 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 52,732.50
GST (18%): ₹ 9,491.85
Total Price: ₹ 62,224.35
Antigen
JAK2
Classification
Monoclonal
Concentration
Conc. Not Determined
Formulation
ascites with 0.03% sodium azide
Gene Accession No.
O60674
Gene Symbols
JAK2
Immunogen
Purified recombinant fragment of JAK2(745-955aa) expressed in E. Coli.
Regulatory Status
RUO
Gene ID (Entrez)
3717
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
ELISA, Western Blot
Clone
1C1
Conjugate
Unconjugated
Gene
JAK2
Gene Alias
EC 2.7.10.2; Fd17; JAK 2; JAK2; JAK-2; Janus kinase 2; Janus kinase 2 (a protein tyrosine kinase); JTK 10; JTK10; kinase Jak2; THCYT3; Tyrosine-protein kinase JAK2
Host Species
Mouse
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG1
Related Products
Description
- MA5-15632 targets JAK2 in indirect ELISA, WB applications and shows reactivity with Human samples
- The MA5-15632 immunogen is purified recombinant fragment of JAK2(745-955aa) expressed in E
- Coli.<br>
- MA5-15632 detects JAK2 which has a predicted molecular weight of approximately 130.6kDa
- Janus kinase 2 (JAK2) is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways and is mutated in polycythemia vera
- This kinase contains the catalytic domain (JH1) of JAK2
- The activation of JAKs can lead to the phosphorylation of STAT (signal transducers and activatiors of transcription) proteins, which dimerize and translocate to the nucleus
- Once translocated to the nucleus, the STAT proteins can modify transcription of numerous genes, including interferon-stimulated genes
- JAK2 is required for the IFN gamma-receptor complex initiation and JAK1 functions as an amplifier
- Some studies have suggested that the role of JAK2 might be performed by Tyk2 and JAK3, if they were positioned correctly within the IFN gamma-receptor complex
- Mutations affecting JAK2 can cause Budd-Chiari syndrome, Polycythemia vera, Thrombocythemia 3, myelofibrosis, or Acute myelogenous leukemia.