Cyclin B1 Monoclonal Antibody (1B10), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA515706-Each-of-1 | In Stock | ₹ 50,151.50 |
PIMA515706 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 50,151.50
GST (18%): ₹ 9,027.27
Total Price: ₹ 59,178.77
Antigen
Cyclin B1
Classification
Monoclonal
Concentration
Conc. Not Determined
Formulation
ascites with 0.03% sodium azide
Gene Accession No.
P14635, P30277
Gene Symbols
Ccnb1
Immunogen
Purified recombinant fragment of human CCNB1 expressed in E. Coli.
Regulatory Status
RUO
Gene ID (Entrez)
25203, 891
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
ELISA, Immunohistochemistry, Western Blot
Clone
1B10
Conjugate
Unconjugated
Gene
Ccnb1
Gene Alias
Ccn-2; CCNB; Ccnb1; Ccnb1-rs1; Ccnb1-rs13; Cycb; Cycb1; Cycb1-rs1; Cycb-4; Cycb-5; cyclin B; cyclin B1; cyclin B1, related sequence 1; cyclin B1, related sequence 13; G2/mitotic-specific cyclin B1; G2/mitotic-specific cyclin-B1; I79_013589; OTTHUMP00000221981; OTTHUMP00000223023
Host Species
Mouse
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Rat
Product Type
Antibody
Isotype
IgG1
Related Products
Description
- MA5-15706 targets CCNB1 in indirect ELISA, IHC and WB applications and shows reactivity with Human samples
- The MA5-15706 immunogen is purified recombinant fragment of human CCNB1 expressed in E
- Coli
- MA5-15706 detects CCNB1 which has a predicted molecular weight of approximately 60kDa
- Cyclins bind to and regulate the activity of the Cyclin dependent protein kinases (CDKs)
- Cyclin B1 or CCNB1 is a regulatory protein involved in mitosis
- It is essential for the control of the cell cycle at the G2/M transition
- Cyclin B1 complexes with p34 (cdc2) to form the maturation-promoting factor (MPF)
- Two alternative transcripts have been found, a constitutively expressed transcript and a cell cycle-regulated transcript, that is expressed predominantly during G2/M phase
- Cyclin B1 is not ubiquitinated during G2/M phase, resulting in its steady accumulation during G2 phase, followed by abrupt APC dependent destruction at the end of mitosis
- Destruction of Cyclin B1 is required for cell cycle progression
- Cyclin B1 is overexpressed in various cancers, including breast, prostate, and non-small cell lung cancer.