OPA1 Monoclonal Antibody (1E8-1D9), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA516149-Each-of-1 | In Stock | ₹ 53,133.00 |
PIMA516149 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 53,133.00
GST (18%): ₹ 9,563.94
Total Price: ₹ 62,696.94
Antigen
OPA1
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
PBS with 0.02% sodium azide
Gene Accession No.
O60313, P58281, Q2TA68
Gene Symbols
OPA1
Immunogen
Human OPA1.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Bovine, Hamster, Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG1 κ
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Clone
1E8-1D9
Conjugate
Unconjugated
Gene
OPA1
Gene Alias
1200011N24Rik; AI225888; AI847218; BERHS; Dynamin-like 120 kDa protein, form S1; Dynamin-like 120 kDa protein, mitochondrial; dynamin-like guanosine triphosphatase; EMBL:AAI11072.1}; hypothetical protein; KIAA0567; Large GTP-binding protein; largeG; lilr3; MGM1; mitochondrial dynamin-like GTPase; mitochondrial OPA1; mKIAA0567; MTDPS14; NPG; NTG; OPA1; opa1 {ECO:0000312; OPA1 mitochondrial dynamin like GTPase; OPA1, mitochondrial dynamin like GTPase; optic atrophy 1; optic atrophy 1 (autosomal dominant); optic atrophy 1 homolog; optic atrophy 1-like protein; optic atrophy protein 1; Optic atrophy protein 1 homolog; RCJMB04_1m16; RN protein
Host Species
Mouse
Purification Method
Protein G
Regulatory Status
RUO
Gene ID (Entrez)
100751873, 171116, 4976, 524142, 74143
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- In Western blot, multiple protein isoforms can be seen at approximately 90, 80 and 65 kDa
- OPA1 is a dynamin-related GTPase that is critical for the maintenance of mitochondrial morphology and mtDNA
- The most commonly associated phenotype with OPA1 mutations is heterozygous optic atrophy, a heterozygous dominant trait that causes reduced visual clarity and sometimes blindness
- The disease usually begins in childhood and increases in severity throughout the life of affected individuals
- Usually, this phenotype is attributed to the degeneration of optic nerve fibers
- Interestingly, the same type of nerve degeneration seems to be partially causative of certain schizophrenia characteristics
- OPA1 dysfunction also seems to be implicated in this case; mitochondrial networks associated with critical nerves seem to link schizophrenia and OPA1
- The dysfunction is associated with issues with apoptosis and normal cellular metabolic regulation, all regulated through OPA1.