p73 delta Monoclonal Antibody (38C674.2), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA516183-Each-of-1 | In Stock | ₹ 49,973.50 |
PIMA516183 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 49,973.50
GST (18%): ₹ 8,995.23
Total Price: ₹ 58,968.73
Antigen
p73 delta
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
PBS with 0.05% BSA and 0.05% sodium azide
Gene Accession No.
O15350, Q9JJP2
Gene Symbols
TP73, Trp73
Immunogen
Synthetic peptide (LYVGDPARHLAT) of p73 (deltaNp73) protein.
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG1 κ
Applications
ChIP Assay, Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Clone
38C674.2
Conjugate
Unconjugated
Gene
TP73
Gene Alias
deltaNp73; OTTHUMP00000003479; OTTHUMP00000003480; p53-like transcription factor; p53-related protein; P73; RP23-254N4.10; TAp73; TP73; transformation related protein 73; Trp73; Tumor protein p73
Host Species
Mouse
Purification Method
Protein G
Regulatory Status
RUO
Gene ID (Entrez)
22062, 362675, 7161
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- Description p73 was identified as a long-lost cousin of tumor suppressor protein, p53 (4)
- p73 has high homology with p53 as well as with p63, a gene implicated in the maintenance of epithelial stem cells
- Significant homology between p53, p63, and p73 (approximately 63% amino acid identity in the DNA-binding domain suggest that they may have overlapping functions in the regulation of gene expression (3)
- The targeted disruption of p73 gene leads to defects hippocampal dysgenesis, hydrocephalus, chronic inflammation and infections (2)
- Recently, spilicing variant mRNAs of p73 has been identified in MCF-7, a breast carcinoma cell line
- These mRNAs code for variant p73 proteins bearing distinct carboxy-terminal structures suggesting that the carboxy-terminal region of p73 may be important for the functions of this protein (1) It was found p73 to be upregulated in a significant fraction of anaplastic thyroid cancers, whereas it was not detectable in normal thyroid epithelial cells nor in papillary or follicular thyroid cancer.