Podoplanin Monoclonal Antibody (NZ-1.2), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA516267-Each-of-1 | In Stock | ₹ 53,044.00 |
PIMA516267 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 53,044.00
GST (18%): ₹ 9,547.92
Total Price: ₹ 62,591.92
Antigen
Podoplanin
Classification
Monoclonal
Concentration
1.0 mg/mL
Formulation
PBS with 0.02% sodium azide
Gene Accession No.
Q86YL7
Gene Symbols
PDPN
Immunogen
Synthetic peptide corresponding to amino acids 38-70 (EGGVAMPGAEDDVV) from the platelet-aggregation-stimulating (PLAG) domain of human podoplanin
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG2a λ
Applications
Flow Cytometry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot
Clone
NZ-1.2
Conjugate
Unconjugated
Gene
PDPN
Gene Alias
29kDa cytosolic podoplanin intracellular domain; Aggrus; CTA-520D8.1; E11; E11 antigen epitope; epithelial cell surface transmembrane protein antigen; glycoprotein 36; Glycoprotein 38; glycoprotein, 36-KD; GP36; Gp38; GP40; HT1A-1; hT1alpha-1; hT1alpha-2; lung type I cell membrane associated glycoprotein; lung type-I cell membrane-associated glycoprotein (T1A-2); Ots8; OTS-8; OTTHUMP00000009640; OTTHUMP00000044504; PA2.26; PA2.26 antigen; PDPN; PICD; Podoplanin; PSEC0003; PSEC0025; pulmonary type I alveolar epithelial cell transmembrane differentiation marker; RANDAM-2; RP23-348F1.2; RTI140; RTI40; T1a; T1A2; T1A-2; T1alpha; T1-alpha; TI1A; Transmembrane glycoprotein E11; type I cell 40 kDa protein
Host Species
Rat
Purification Method
Protein G
Regulatory Status
RUO
Gene ID (Entrez)
10630
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- Podoplanin (PDPN, T1A, gp38, Aggrus) is a mucin type-1 glycoprotein with a 40-43 kDa molecular weight
- Podoplanin is expressed in many tumors and normal cells, especially lymphatic epithelial cells and follicular DCs
- Podoplanin localizes in stromal cells of peripheral lymphoid tissue and thymic epithelial cells
- As a regulator of the lymphatic endothelium, podoplanin probably plays a role in maintaining the unique shape of podocytes
- Podoplanin appears to serve as a ligand for CLEC-2 and expression is positively correlated with tumors expressing greater invasive and metastatic potential
- Podoplanin is directly involved in cell migration, aids metastases formation and tumor cell invasion of tissue
- Further, it has also been determined that podoplanin expression is induced through Src activation of Cas and, recently, there are indications of podoplanin presence on Th17 cells
- Initial studies below indicate the presence of podoplanin on a small but distinct population of CD4+ cells from human PBMC
- Dysfunction of the podoplanin protein has been linked to diseases such as lymphangioma and subglottis neoplasm
- Podoplanin has also been proposed as a marker for lung injury due to the physiological function of the protein.