CD103 Monoclonal Antibody (LF61), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA516774-Each-of-1 | In Stock | ₹ 50,240.50 |
PIMA516774 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 50,240.50
GST (18%): ₹ 9,043.29
Total Price: ₹ 59,283.79
Antigen
CD103
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
PBS with 0.09% sodium azide
Gene Accession No.
P38570
Gene Symbols
Itgae
Immunogen
Hairy cell leukaemia cells
Quantity
200 μg
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG1
Applications
Flow Cytometry, Immunohistochemistry (Frozen), Immunoprecipitation
Clone
LF61
Conjugate
Unconjugated
Gene
Itgae
Gene Alias
A530055J10; alpha-E1; alpha-M290; aM290; antigen CD103; antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide; CD103; DC; DCs; HML-1 antigen; human mucosal lymphocyte antigen 1, alpha polypeptide; HUMINAE; integrin alpha E; integrin alpha E, epithelial-associated; integrin alpha E1, epithelial-associated; integrin alpha M290; Integrin alpha-E; Integrin alpha-E heavy chain; Integrin alpha-E light chain; Integrin alpha-IEL; integrin subunit alpha E; integrin, alpha E; integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide); integrin, alpha E, epithelial-associated; Intregrin alpha E2; Itgae; MGC141996; Mucosal lymphocyte 1 antigen
Host Species
Mouse
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
3682
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
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Description
- The epitope recognized by this antibody is reported to be sensitive to formaldehyde fixation and tissue processing
- We recommend the use of acetone fixation for frozen sections
- For FACS analysis, use 10 μL of the suggested working dilution to label 1x10^6 cells in 100 μL
- CD103 (ITGAE, Integrin alpha E) is molecule that is expressed on mucosa-associated T lymphocytes and activated cells and on subet of TGF beta -1 cells
- In particular, CD103 includes a 150kDa alpha chain and a 120kDa beta chain
- CD103 is expressed by 0.5 to 2% of resting lymphocytes in peripheral blood and lymphoid organs
- CD103 antibody stains a few bone marrow cells and, rarely, peripheral blood lymphocytes
- CD103 is part of the integrin family which are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain
- ITGAE encodes an I-domain-containing alpha integrin that undergoes post-translational cleavage in the extracellular domain, yielding disulfide-linked heavy and light chains
- In combination with the beta 7 integrin, CD103 protein forms the E-cadherin binding integrin known as the human mucosal lymphocyte-1 antigen
- CD103 is preferentially expressed in human intestinal intraepithelial lymphocytes (IEL), and in addition to a role in adhesion, it may serve as an accessory molecule for IEL activation
- Diseases associated with CD103 dysfunction include hairy cell leukemia and splenic marginal zone lymphoma.