CD43 Monoclonal Antibody (W3/13), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA516976-Each-of-1 | In Stock | ₹ 87,264.50 |
PIMA516976 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 87,264.50
GST (18%): ₹ 15,707.61
Total Price: ₹ 1,02,972.11
Antigen
CD43
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
PBS with 0.09% sodium azide
Gene Accession No.
P13838
Gene Symbols
SPN
Immunogen
Rat thymocyte membrane glycoproteins
Quantity
1 mg
Primary or Secondary
Primary
Target Species
Rat
Product Type
Antibody
Isotype
IgG1
Applications
Flow Cytometry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin)
Clone
W3/13
Conjugate
Unconjugated
Gene
SPN
Gene Alias
3E8 antigen; A630014B01Rik; B-cell differentiation antigen LP-3; CD43; CD43 cytoplasmic tail; CD43-ct; Galactoglycoprotein; GALGP; gpL115; Leukocyte sialoglycoprotein; leukosialin; leukosianin; LOC101120462; LOW QUALITY PROTEIN: leukosialin; Lsn; Lsn1; Ly48; Ly-48; Lymphocyte antigen 48; sialophorin; sialophorin (gpL115, leukosialin, CD43); sialophorin gpL115; SPN; W3/13 antigen
Host Species
Mouse
Purification Method
Protein G
Regulatory Status
RUO
Gene ID (Entrez)
24796
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
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Description
- Heat-mediated antigen retrieval is recommended for the staining of paraffin sections
- For FACS analysis, use 10 μL of the suggested working dilution to label 1x10^6 cells in 100 μL
- CD43 (leukosialin, sialophorin) is a transmembrane mucin-like protein with high negative charge, expressed on the surface of most hematopoietic cells
- CD43 contributes to a repulsive barrier that interferes with cellular adhesion, however, in certain cases also promotes leukocyte aggregation
- By interaction with actin-binding proteins ezrin and moesin CD43 plays a regulatory role in remodeling T-cell morphology and regulates cell-cell interactions during lymphocyte traffic
- CD43 signaling both enhances LFA-1 adhesiveness and counteracts LFA-1 induction via other receptors
- Expression of CD43 causes induction of functionally active tumor suppressor p53 protein, but in case of p53 and ARF deficiency CD43 promotes tumor proliferation and viability
- CD43 appears to be an important modulator of leukocyte functions
- Diseases associated with CD43 dysfunction include Wiscott-Aldrich Syndrome and Adenoid Basal Cell Carcinoma.