ROCK1 Monoclonal Antibody (1H4), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA517165-Each-of-1 | In Stock | ₹ 50,062.50 |
PIMA517165 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 50,062.50
GST (18%): ₹ 9,011.25
Total Price: ₹ 59,073.75
Antigen
ROCK1
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
PBS with 0.05% sodium azide
Gene Accession No.
Q13464
Gene Symbols
Rock1
Immunogen
Purified recombinant fragment of human ROCK1 expressed in E. Coli.
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG1
Applications
ELISA, Western Blot
Clone
1H4
Conjugate
Unconjugated
Gene
Rock1
Gene Alias
1110055K06Rik; Ac2-154; Liver regeneration-related protein LRRG199; MGC131603; MGC43611; p150 RhoA-binding kinase ROK beta; p160 ROCK-1; p160ROCK; p160-ROCK; PRO0435; Renal carcinoma antigen NY-REN-35; Rho associated coiled-coil containing protein kinase 1; Rho kinase; Rho-associated coiled-coil containing protein kinase 1; Rho-associated coiled-coil forming kinase 1; Rho-associated kinase beta; rho-associated protein kinase 1; Rho-associated, coiled-coil containing protein kinase 1; rho-associated, coiled-coil-containing protein kinase 1; Rho-associated, coiled-coil-containing protein kinase I; ROCK1; ROCK-I
Host Species
Mouse
Purification Method
Protein G
Regulatory Status
RUO
Gene ID (Entrez)
6093
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- MA5-17165 targets ROCK1 in indirect ELISA and WB applications and shows reactivity with Human samples
- The MA5-17165 immunogen is purified recombinant fragment of human ROCK1 expressed in E
- Coli
- MA5-17165 detects ROCK1 which has a predicted molecular weight of approximately 158kDa
- ROCK1 is a serine/threonine kinase that regulates cell differentiation and migration
- The Rho/ROCK pathway is involved in the progression of various human cancers
- ROCK1 has been found to be a new Caspase-3 substrate
- ROCK, one of the effectors of the small GTPase Rho, has recently been shown to contribute significantly to myosin light chain (MLC) activation through two pathways: direct phosphorylation of MLC and phosphorylation of MLC phosphatase, leading to its inhibition
- The increase in cellular contractility that is necessary for apoptotic membrane blebbing implies sustained augmentation of MLC phosphorylation
- ROCK-1 consists of an amino-terminal kinase domain and an inhibitory cysteine/histidine-rich C-terminal domain that is located within a pleckstrin-homology region
- They are joined by a variable region that contains the Rho-binding domain
- During apoptosis, ROCK-I is cleaved by caspase-3 at a conserved DETD1113/G sequence and its carboxy-terminal inhibitory domain is removed, resulting in deregulated and constitutive kinase activity
- The caspase-3-mediated cleavage and activation of ROCK I induces phosphorylation of MLC and membrane blebbing, one of the first events in the execution phase of apoptosis.