RCAN2 Monoclonal Antibody (1A9), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA524549-Each-of-1 | In Stock | ₹ 47,036.50 |
PIMA524549 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 47,036.50
GST (18%): ₹ 8,466.57
Total Price: ₹ 55,503.07
Antigen
RCAN2
Classification
Monoclonal
Conjugate
Unconjugated
Gene
Rcan2
Gene Alias
calcineurin inhibitory protein ZAKI-4; Calcipressin-2; caskin-1-like; CSP2; Dcip2; Down syndrome candidate region 1-like 1; down syndrome candidate region 1-like protein 1; Down syndrome critical region gene 1-like 1; Down syndrome critical region gene 1-like 1 protein; Down syndrome critical region gene1-like 1; DSCR1L1; DSCR1L1 protein; LOW QUALITY PROTEIN: calcipressin-2; MCIP2; myocyte-enriched calcineurin interactin protein 2; myocyte-enriched calcineurin-interacting protein 2; Rcan2; RCN2; regulator of calcineurin 2; si:ch211-124g24.1; thyroid hormone-responsive (skin fibroblasts); thyroid hormone-responsive protein ZAKI-4; translation initiation factor IF-2; ZAKI4; ZAKI-4; zgc:85746
Host Species
Mouse
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
10231
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
ELISA, Western Blot
Clone
1A9
Formulation
PBS with no preservative; pH 7.4
Gene Accession No.
Q14206
Gene Symbols
Rcan2
Immunogen
RCN2 (AAH04892.1, 24 a.a. ∽ 317 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG1 κ
Related Products
Description
- Peptide Sequence: KAEELHYPLG ERRSDYDREA LLGVQEDVDE YVKLGHEEQQ KRLQAIIKKI DLDSDGFLTE SELSSWIQMS FKHYAMQEAK QQFVEYDKNS DDTVTWDEYN IQMYDRVIDF DENTALDDAE EESFRKLHLK DKKRFEKANQ DSGPGLSLEE FIAFEHPEEV DYMTEFVIQE ALEEHDKNGD GFVSLEEFLG DYRWDPTANE DPEWILVEKD RFVNDYDKDN DGRLDPQELL PWVVPNNQGI AQEEALHLID EMDLNGDKKL SEEEILENPD LFLTSEATDY GRQLHDDYFY HDEL Regulator of calcineurin 2 (RCAN2), also known as ZAKI4 and DSCR1L1, is expressed as two isoforms differing at their N-terminus
- The longer of the two (isoform 1) is expressed exclusively in the brain, while isoform 2 is ubiquitously expressed, with highest expression in brain, heart, and muscle
- Both isoforms bind to the catalytic subunit of calcineurin, a Ca++-dependent protein phosphatase involved in several neuronal functions, though their C-terminal region and inhibit calcineurin's activity
- Unlike isoform 1 of RCAN2, the expression of the second isoform is not induced by the thyroid hormone T3
- RCAN2 is a member of a family of three endogenous calcineurin regulators that are located near the minimal supernumerary fragment of chromosome 21 in individuals with Down syndrome, suggesting that they play a role in this syndrome
- Multiple isoforms of RCAN2 are known to exist.