PIMA525543
CRY2 Monoclonal Antibody (OTI1H5), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA525543-Each-of-1 | In Stock | ₹ 52,287.50 |
PIMA525543 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 52,287.50
GST (18%): ₹ 9,411.75
Total Price: ₹ 61,699.25
Antigen
CRY2
Classification
Monoclonal
Concentration
0.78 mg/mL
Formulation
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.
Q49AN0
Gene Symbols
CRY2
Immunogen
Full length human recombinant protein of CRY2 produced in HEK293T cell
Quantity
100μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG2a
Applications
Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Clone
OTI1H5
Conjugate
Unconjugated
Gene
CRY2
Gene Alias
AV006279; CRY2; cryptochrome 2 (photolyase-like); cryptochrome circadian clock 2; cryptochrome-2; D130054K12Rik; growth-inhibiting protein 37; HCRY2; Kiaa0658; PHLL2
Host Species
Mouse
Purification Method
Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
1408
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Related Products
Description
- Various biochemical, physiological and behavioral processes display circadian rhythms controlled by an internal biological clock
- The central "egears"e driving this clock appear to be composed of an autoregulatory transcription/post translation-based feedback loop
- Cryptochrome 1 (CRY1) and 2 (CRY2) are DNA-binding flavoproteins that bear some homology to blue-light receptors and photolyases
- In Drosophila, CRY is a photoreceptor for the circadian clock where it binds to the clock component TIM in a light-dependent fashion and blocks its function
- Mammalian CRY1 and CRY2 function via light-independent interactions with circadian genes CLOCK and BMAL1, as well as with PER1, PER2, and TIM
- They seem to act as light-independent components of the circadian clock and likely regulate Per1 transcriptional cycling via interactions with both the activator and its feedback inhibitors
- Mutant mice not expressing the Cry1 or Cry2 protein display accelerated and delayed periodicity of locomotor activity, respectively
- It appears that the combination of both proteins working together is essential to synchronize the organism to circadian phases
- A critical balance between Cry1 and Cry2 is required for proper clock function; in complete darkness, double-mutant mice present with instantaneous arrhythmicity, indicating the absence of an internal circadian clock.