PDE6 gamma Monoclonal Antibody (OTI2F5), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA525732-Each-of-1 | In Stock | ₹ 52,198.50 |
PIMA525732 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 52,198.50
GST (18%): ₹ 9,395.73
Total Price: ₹ 61,594.23
Antigen
PDE6 gamma
Classification
Monoclonal
Concentration
0.72 mg/mL
Formulation
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.
P18545
Gene Symbols
PDE6G
Immunogen
Full length human recombinant protein of PDE6G produced in HEK293T cell
Quantity
100μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG2b
Applications
Immunohistochemistry (Paraffin), Western Blot
Clone
OTI2F5
Conjugate
Unconjugated
Gene
PDE6G
Gene Alias
GMP-PDE gamma; p3AT; PDE6G; PDEG; phosphodiesterase 6G; phosphodiesterase 6G, cGMP-specific, rod, gamma; phosphodiesterase, cyclic GMP (rod receptor), gamma polypeptide; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma; rod cG-PDE G; RP57; unnamed protein product
Host Species
Mouse
Purification Method
Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
5148
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Related Products
Description
- The second messengers cAMP and cGMP are key regulatory molecules that are involved in a wide variety of signal transduction pathways
- Levels of cAMP and cGMP are regulated by their rate of synthesis by nucleotide cyclases and by their rate of hydrolysis by cyclic nucleotide phosphodiesterases (PDEs)
- PDEs form a superfamily of enzymes that catalyze the conversion of 3-prime, 5-prime-cyclic nucleotides to the corresponding nucleoside 5-prime-monophosphates
- PDE6 is the effector enzyme in the G protein-mediated signal transduction cascade in the visual system
- There are five different subunits consisting of rod and cone specific catalytic subunits: alpha' (Cone), alpha (Rod), and beta (Rod), the inhibitory subunit gamma, and subunit delta of unknown function (which likely interacts with many other proteins besides the PDE6 family)
- The catalytic core of the PDE6 system is comprised of alpha'/alpha' homodimers in the cone and alpha/beta heterodimers in the rod
- The C-terminus of both the catalytic and inhibitory subunits is modified by methylation, myristyolation and prenylation which have been shown to be critical for proper complex assembly and membrane association.