RYBP Monoclonal Antibody (OTI2B4), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA525946-Each-of-1 | In Stock | ₹ 52,198.50 |
PIMA525946 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 52,198.50
GST (18%): ₹ 9,395.73
Total Price: ₹ 61,594.23
Antigen
RYBP
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.
Q8CCI5, Q8N488
Gene Symbols
Rybp
Immunogen
Full length human recombinant protein of RYBP produced in E.coli
Quantity
100μL
Primary or Secondary
Primary
Target Species
Canine, Human, Mouse, Non-human Primate
Product Type
Antibody
Isotype
IgG1
Applications
Western Blot
Clone
OTI2B4
Conjugate
Unconjugated
Gene
Rybp
Gene Alias
2410018J24Rik; AAP1; APAP-1; apoptin-associating protein 1; Death effector domain-associated factor; DEDAF; DED-associated factor; RING1 and YY1 binding protein; RING1 and YY1-binding protein; ring1 interactor RYBP; Rybp; YEAF1; YY1 and E4TF1 associated factor 1; YY1 and E4TF1-associated factor 1
Host Species
Mouse
Purification Method
Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
23429, 484690, 56353
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Related Products
Description
- RYBP involves component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development
- PcG PRC1-like complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility
- Component of a PRC1-like complex that mediates monoubiquitination of histone H2A 'Lys-119' on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females
- May stimulate ubiquitination of histone H2A 'Lys-119' by recruiting the complex to target sites
- Inhibits ubiquitination and subsequent degradation of TP53, and thereby plays a role in regulating transcription of TP53 target genes
- May also regulate the ubiquitin-mediated proteasomal degradation of other proteins like FANK1 to regulate apoptosis
- May be implicated in the regulation of the transcription as a repressor of the transcriptional activity of E4TF1
- May bind to DNA
- May play a role in the repression of tumor growth and metastasis in breast cancer by down-regulating SRRM3.