SnoN Monoclonal Antibody (OTI2C9), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA526387-Each-of-1 | In Stock | ₹ 52,198.50 |
PIMA526387 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 52,198.50
GST (18%): ₹ 9,395.73
Total Price: ₹ 61,594.23
Antigen
SnoN
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.
P12757
Gene Symbols
SKIL
Immunogen
Human recombinant protein fragment corresponding to amino acids 307-684 of SKIL produced in E.coli
Quantity
100μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG1
Applications
Immunohistochemistry (Paraffin), Western Blot
Clone
OTI2C9
Conjugate
Unconjugated
Gene
SKIL
Gene Alias
EGK_11909; LOW QUALITY PROTEIN: ski-like protein; SKI like proto-oncogene; ski/sno related; SKIL; SKI-like; SKI-like oncogene; ski-like protein; ski-like protein-like; SKI-like proto-oncogene; Skir; ski-related oncogene; ski-related oncogene snoN; Ski-related protein; SNO; SnoA; SnoI; SnoN; v-ski sarcoma viral oncogene homolog
Host Species
Mouse
Purification Method
Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
6498
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Related Products
Description
- TGF-beta is a ubiquitously expressed cytokine that signals through the Smad protein family to regulate numerous cellular processes such as embryonic development and tumorigenesis
- This signaling is negatively regulated by Ski, the mammalian homolog of the transforming protein of an avian retrovirus that induces oncogenic transformation of chicken embryo cells, and the related protein SnoN
- Like Ski, SnoN functions by binding to the Smad proteins and preventing their phosphorylation, thereby inhibiting their ability to bind DNA and activate the transcription of downstream genes
- SnoN is located primarily in the nucleus in cancer tissues or cells, but in the cytoplasm in normal tissues or primary epithelial cells.