Calponin 1 Recombinant Rabbit Monoclonal Antibody (RM262), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA527892-Each-of-1 | In Stock | ₹ 49,884.50 |
PIMA527892 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 49,884.50
GST (18%): ₹ 8,979.21
Total Price: ₹ 58,863.71
Antigen
Calponin 1
Classification
Recombinant Monoclonal
Concentration
0.1 mg/mL
Formulation
PBS with 1% BSA, 50% glycerol and 0.09% sodium azide
Gene Accession No.
P51911, Q08091
Gene Symbols
CNN1
Immunogen
A peptide corresponding to the C-terminus of human Calponin-1
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse
Product Type
Antibody
Isotype
IgG
Applications
Immunocytochemistry, Western Blot
Clone
RM262
Conjugate
Unconjugated
Gene
CNN1
Gene Alias
Basic calponin; calponin; calponin 1; calponin 1, basic, smooth muscle; calponin 1, smooth muscle; calponin H1, smooth muscle; Calponin-1; calponins, basic; CN; CNN1; CnnI; epididymis secretory protein Li 14; h1-calponin; HEL-S-14; similar to calponin 1, basic, smooth muscle; Sm-Calp; SMCC; smooth muscle calponin h1
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
1264, 12797
Content And Storage
-20°C
Form
Liquid
Related Products
Description
- Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
- The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
- Then, individual clones are screened to select the best candidates for production
- The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
- Calponin, a thin filament associated protein is implicated in the regulation and modulation of smooth muscle contraction
- It is capable of binding to actin, calmodulin, troponin C and tropomyosin
- Calponin is expressed in smooth muscle and tissues containing significant amounts of smooth muscle
- Two isoforms of calponin exist whose molecular weights are 34kDa and 29kDa
- Expression of the 29kDa form is primarily restricted to muscle of the urogenital tract
- The expression of calponin has also been demonstrated in myoepithelial cells from benign and malignant breast lesions
- It stains smooth muscle, myoepithelial cells, myofibroblasts, keratinocytes and nerve fibers
- It identifies myoepithelial cells in breast lesions, and helps differentiate breast collagenous spherulosis (positive) from adenoid cystic carcinoma
- Adenoid cystic carcinoma in salivary gland tumors is calponin positive.