EGFR Monoclonal Antibody (EGFR1), PE, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA528544-Each-of-1 | In Stock | ₹ 35,021.50 |
PIMA528544 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 35,021.50
GST (18%): ₹ 6,303.87
Total Price: ₹ 41,325.37
Antigen
EGFR
Classification
Monoclonal
Conjugate
PE
Gene
EGFR
Gene Alias
2.7.10.1; 9030024J15Rik; AI552599; avian erythroblastic leukemia viral (v-erbB) oncogene homolog; avian erythroblastic leukemia viral (v-erb-b) oncogene homolog; cell growth inhibiting protein 40; cell proliferation-inducing protein 61; EC 2.7.10.1; egf receptor; Egfr; EGFR-related peptide; epidermal growth factor receptor; epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian); Epidermal growth factor receptor formerly avian erythroblastic leukemia viral (v-erbB) oncogene homolog (Erbb1); epidermal growth factor receptor, formerly avian erythroblastic leukemia viral (v-erbB) oncogene homolog (Erbb1); ERBB; ERBB1; ErbB-1; erb-b2 receptor tyrosine kinase 1; Errb1; Errp; HER1; kinase EGFR; mENA; NISBD2; Oncogene ERBB; PIG61; Proto-oncogene c-ErbB-1; receptor tyrosine-protein kinase erbB-1; Urogastrone; wa2; wa-2; Wa5; waved 2
Host Species
Mouse
Purification Method
Size-exclusion chromatography
Regulatory Status
RUO
Gene ID (Entrez)
100067755, 1956
Content And Storage
4° C, store in dark, DO NOT FREEZE!
Form
Liquid
Applications
Flow Cytometry
Clone
EGFR1
Formulation
PBS with 0.2% BSA and 15mM sodium azide; pH 7.4
Gene Accession No.
P00533
Gene Symbols
EGFR
Immunogen
Human epidermoid carcinoma line A431
Quantity
100 Tests
Primary or Secondary
Primary
Target Species
Equine, Human
Product Type
Antibody
Isotype
IgG2b κ
Related Products
Description
- The mouse monoclonal antibody EGFR1 reacts with extracellular domain of human protein kinase EGFR (ErbB1 / HER1); epitope within amino acids 6-273
- Recommended dilution is for 100 μL of whole blood or 1x10^6 cells in suspension
- EGFR, epidermal growth factor receptor, is a receptor tyrosine kinases that signals in response to various growth factors
- Overexpression has been linked to numerous types of cancer and EGFR is the target of both biological and small molecular therapeutics
- EGFR is encoded by the EGFR gene located on chromosome 7 in humans
- EGFR belongs to the HER/ERbB family of proteins that includes three other receptor tyrosine kinases, ERbB2, ERbB3, ERbB4
- EGFR is a transmembrane receptor and binding of its cognate ligands such as EGF (Epidermal Growth Factor) and TGF alpha (Transforming Growth Factor alpha) to the extracellular domain leads to EGFR dimerization followed by autophosphorylation of the tyrosine residues in the cytoplasmic domain
- Overexpression is observed in tumors of the head and neck, brain, bladder, stomach, breast, lung, endometrium, cervix, vulva, ovary, esophagus, stomach and in squamous cell carcinoma.