DIABLO Recombinant Rabbit Monoclonal Antibody (006), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA529220-Each-of-1 | In Stock | ₹ 41,385.00 |
PIMA529220 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 41,385.00
GST (18%): ₹ 7,449.30
Total Price: ₹ 48,834.30
Antigen
DIABLO
Classification
Recombinant Monoclonal
Concentration
1 mg/mL
Formulation
PBS with no preservative; pH 7
Gene Accession No.
Q9NR28
Gene Symbols
DIABLO
Immunogen
Recombinant Human SMAC/Diablo protein (Ala56-Asp239)
Quantity
100μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Applications
ELISA, Flow Cytometry, Immunocytochemistry, Western Blot
Clone
006
Conjugate
Unconjugated
Gene
DIABLO
Gene Alias
0610041G12Rik; 1700006L01Rik; AU040403; DFNA64; DIABLO; diablo homolog (Drosophila); diablo homolog, mitochondrial; diablo IAP-binding mitochondrial protein; diablo, IAP-binding mitochondrial protein; diablo-like protein; DIABLO-S; direct IAP binding protein with low PI; direct IAP-binding protein with low pI; FLJ10537; FLJ25049; hCG_1782202; Second mitochondria-derived activator of caspase; Smac; Smac protein; SMAC3
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
56616
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- This product is preservative free
- It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%)
- Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
- The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
- Then, individual clones are screened to select the best candidates for production
- The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
- This antibody has specificity for Human SMAC/Diablo
- DIABLO (smac), a mitochondrial protein, activates various forms of apoptosis
- This activation may be due to the neutralization of one or more members of the IAP family of apoptosis inhibitory proteins
- Smac exits the mitochondria and enter the cytosol during certain apoptosis triggered events
- Mitochondrial-mediated apoptosis is important in animal development and tissue homeostasis, with alterations resulting in a range of malignant disorders
- Upon apoptotic stimuli, the mitochondrial proteins cytochrome c and Smac/DIABLO are released into the cytosol
- The release of these proteins, however, occurs via different mechanisms
- Smac/DIABLO has also been found to play a key role in regulating the sensitization of cancer cells to apoptosis (both immune and drug-induced).