PIMA530094
BPI Monoclonal Antibody (04), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA530094-Each-of-1 | In Stock | ₹ 32,485.00 |
PIMA530094 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 32,485.00
GST (18%): ₹ 5,847.30
Total Price: ₹ 38,332.30
Antigen
BPI
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
PBS with no preservative
Gene Accession No.
P17213
Gene Symbols
BPI
Immunogen
Recombinant Human BPI protein (Met1-Lys487)
Quantity
100μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG1
Applications
ELISA
Clone
04
Conjugate
Unconjugated
Gene
BPI
Gene Alias
9230105K17Rik; Bactericidal permeability-increasing protein; bactericidal permeablility increasing protein; bactericidal/permeability-increasing protein; BPI; BPI fold containing family D, member 1; BPIFD1; CAP 57; rBPI; recombinant BPI holoprotein, rBPI; RP13-218F6_A.1
Host Species
Mouse
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
671
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
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Description
- This product is preservative free
- It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%)
- This antibody has specificity for Human BPI
- The antimicrobial protein BPI is a 55 kDa protein found in the primary (azurophilic) granules of human neutrophils and has also been detected on surface of neutrophils, small intestinal and oral epithelial cells
- BPI is a bactericidal compound that is present in polymorphonuclear cells (PMN) and in lower levels in the specific granules of eosinophils
- BPI possesses high affinity toward the lipid A region of lipopolysaccharides (LPS) that comprise the outer leaflet of the gram-negative bacterial outer membrane
- The binding of BPI to lipid A causes multiple anti-infective activities against gram-negative bacteria
- These include: cytotoxicity via sequential damage to bacterial outer and inner lipid membranes, neutralization of gram-negative bacterial LPS, opsonization of bacteria to enhance phagocytosis by neutrophils
- BPI may be a critical determinant in the development of LPStriggered airways disease since airway epithelial cells constitutively express the BPI gene and produce the BPI protein
- Inflammation induced by LPS possibly contributes to the development of rapid airflow decline, a serious and often fatal complication of hematopoietic cell transplantation
- Furthermore, a 21 kDa bioactive recombinant fragment of BPI, rBPI21, was shown to confer a survival advantage against invasive pneumococcal disease by binding to the gram-positive bacterial pathogen, pneumolysin.